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- Publisher Website: 10.1242/dev.168096
- Scopus: eid_2-s2.0-85056625137
- PMID: 30291162
- WOS: WOS:000451191500015
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Article: Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans
Title | Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans |
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Authors | |
Keywords | Neuronal differentiation Repressors Touch receptor neurons ZEB Cell fate Binary decision |
Issue Date | 2018 |
Publisher | The Company of Biologists Ltd. The Journal's web site is located at https://dev.biologists.org/ |
Citation | Development (Cambridge), 2018, v. 145, n. 22, article no. dev168096 How to Cite? |
Abstract | © 2018. Published by The Company of Biologists Ltd. Terminal differentiation generates the specialized features and functions that allow postmitotic cells to acquire their distinguishing characteristics. This process is thought to be controlled by transcription factors called 'terminal selectors' that directly activate a set of downstream effector genes. In Caenorhabditis elegans, the differentiation of both the mechanosensory touch receptor neurons (TRNs) and the multidendritic nociceptor FLP neurons uses the terminal selectors UNC-86 and MEC-3. The FLP neurons fail to activate TRN genes, however, because a complex of two transcriptional repressors (EGL-44/EGL-46) prevents their expression. Here, we show that the ZEB family transcriptional factor ZAG-1 promotes TRN differentiation not by activating TRN genes but by preventing the expression of EGL-44/EGL-46. As EGL-44/EGL-46 also inhibits the production of ZAG-1, these proteins form a bistable, negative-feedback loop that regulates the choice between the two neuronal fates. |
Persistent Identifier | http://hdl.handle.net/10722/265798 |
ISSN | 2021 Impact Factor: 6.862 2020 SCImago Journal Rankings: 3.754 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Chaogu | - |
dc.contributor.author | Jin, Felix Qiaochu | - |
dc.contributor.author | Trippe, Brian Loeber | - |
dc.contributor.author | Wu, Ji | - |
dc.contributor.author | Chalfie, Martin | - |
dc.date.accessioned | 2018-12-03T01:21:43Z | - |
dc.date.available | 2018-12-03T01:21:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Development (Cambridge), 2018, v. 145, n. 22, article no. dev168096 | - |
dc.identifier.issn | 0950-1991 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265798 | - |
dc.description.abstract | © 2018. Published by The Company of Biologists Ltd. Terminal differentiation generates the specialized features and functions that allow postmitotic cells to acquire their distinguishing characteristics. This process is thought to be controlled by transcription factors called 'terminal selectors' that directly activate a set of downstream effector genes. In Caenorhabditis elegans, the differentiation of both the mechanosensory touch receptor neurons (TRNs) and the multidendritic nociceptor FLP neurons uses the terminal selectors UNC-86 and MEC-3. The FLP neurons fail to activate TRN genes, however, because a complex of two transcriptional repressors (EGL-44/EGL-46) prevents their expression. Here, we show that the ZEB family transcriptional factor ZAG-1 promotes TRN differentiation not by activating TRN genes but by preventing the expression of EGL-44/EGL-46. As EGL-44/EGL-46 also inhibits the production of ZAG-1, these proteins form a bistable, negative-feedback loop that regulates the choice between the two neuronal fates. | - |
dc.language | eng | - |
dc.publisher | The Company of Biologists Ltd. The Journal's web site is located at https://dev.biologists.org/ | - |
dc.relation.ispartof | Development (Cambridge) | - |
dc.subject | Neuronal differentiation | - |
dc.subject | Repressors | - |
dc.subject | Touch receptor neurons | - |
dc.subject | ZEB | - |
dc.subject | Cell fate | - |
dc.subject | Binary decision | - |
dc.title | Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1242/dev.168096 | - |
dc.identifier.pmid | 30291162 | - |
dc.identifier.scopus | eid_2-s2.0-85056625137 | - |
dc.identifier.volume | 145 | - |
dc.identifier.issue | 22 | - |
dc.identifier.spage | article no. dev168096 | - |
dc.identifier.epage | article no. dev168096 | - |
dc.identifier.eissn | 1477-9129 | - |
dc.identifier.isi | WOS:000451191500015 | - |
dc.identifier.issnl | 0950-1991 | - |