File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a

TitleInfertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a
Authors
KeywordsMouse
Oocyte
P13K pathway
Transgenic
Foxo3a
Follicular development
Issue Date2007
Citation
Development, 2007, v. 134, n. 1, p. 199-209 How to Cite?
AbstractIn recent years, mammalian oocytes have been proposed to have important roles in the orchestration of ovarian follicular development and fertility. To determine whether intra-oocyte Foxo3a, a component of the phosphatidylinositol 3-kinase (P13K) signaling pathway, influences follicular development and female fertility, a transgenic mouse model was generated with constitutively active Foxo3a expressed in oocytes. We found that the female transgenic mice were infertile, which was caused by retarded oocyte growth and follicular development, and anovulation. Further mechanistic studies revealed that the constitutively active Foxo3a in oocytes caused a dramatic reduction in the expression of bone morphogenic protein 15 (Bmpl 15), connexin 37 and connexin 43, which are important molecules for the establishment of paracrine and gap junction communications in follides. Foxo3a was also found to facilitate the nuclear localization of P27kip1 in oocytes, a cyclin-dependent kinase (Cdk) inhibitor that may serve to inhibit oocyte growth. The results from the current study indicate that Foxo3a is an important intra-oocyte signaling molecule that negatively regulates oocyte growth and follicular development. Our study may therefore give some insight into oocyte-borne genetic aberrations that cause defects in follicular development and anovulation in human diseases, such as premature ovarian failure.
Persistent Identifierhttp://hdl.handle.net/10722/265780
ISSN
2017 Impact Factor: 5.413
2015 SCImago Journal Rankings: 5.239
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Lian-
dc.contributor.authorRajareddy, Singareddy-
dc.contributor.authorReddy, Pradeep-
dc.contributor.authorDu, Chun-
dc.contributor.authorJagarlamudi, Krishna-
dc.contributor.authorShen, Yan-
dc.contributor.authorGunnarsson, David-
dc.contributor.authorSelstam, Gunnar-
dc.contributor.authorBoman, Karin-
dc.contributor.authorLiu, Kui-
dc.date.accessioned2018-12-03T01:21:40Z-
dc.date.available2018-12-03T01:21:40Z-
dc.date.issued2007-
dc.identifier.citationDevelopment, 2007, v. 134, n. 1, p. 199-209-
dc.identifier.issn0950-1991-
dc.identifier.urihttp://hdl.handle.net/10722/265780-
dc.description.abstractIn recent years, mammalian oocytes have been proposed to have important roles in the orchestration of ovarian follicular development and fertility. To determine whether intra-oocyte Foxo3a, a component of the phosphatidylinositol 3-kinase (P13K) signaling pathway, influences follicular development and female fertility, a transgenic mouse model was generated with constitutively active Foxo3a expressed in oocytes. We found that the female transgenic mice were infertile, which was caused by retarded oocyte growth and follicular development, and anovulation. Further mechanistic studies revealed that the constitutively active Foxo3a in oocytes caused a dramatic reduction in the expression of bone morphogenic protein 15 (Bmpl 15), connexin 37 and connexin 43, which are important molecules for the establishment of paracrine and gap junction communications in follides. Foxo3a was also found to facilitate the nuclear localization of P27kip1 in oocytes, a cyclin-dependent kinase (Cdk) inhibitor that may serve to inhibit oocyte growth. The results from the current study indicate that Foxo3a is an important intra-oocyte signaling molecule that negatively regulates oocyte growth and follicular development. Our study may therefore give some insight into oocyte-borne genetic aberrations that cause defects in follicular development and anovulation in human diseases, such as premature ovarian failure.-
dc.languageeng-
dc.relation.ispartofDevelopment-
dc.subjectMouse-
dc.subjectOocyte-
dc.subjectP13K pathway-
dc.subjectTransgenic-
dc.subjectFoxo3a-
dc.subjectFollicular development-
dc.titleInfertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a-
dc.typeArticle-
dc.description.natureLink_to_OA_fulltext-
dc.identifier.doi10.1242/dev.02667-
dc.identifier.pmid17164425-
dc.identifier.scopuseid_2-s2.0-33846538095-
dc.identifier.volume134-
dc.identifier.issue1-
dc.identifier.spage199-
dc.identifier.epage209-
dc.identifier.isiWOS:000243011000021-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats