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Conference Paper: Long-term outcome of patients with pediatric tectal glioma

TitleLong-term outcome of patients with pediatric tectal glioma
Authors
Keywordsmagnetic resonance imaging
hematoma
subdural
biopsy
endoscopy
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org
Citation
The 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) , Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i108–i109, article no. LGG-21 How to Cite?
AbstractTectal glioma (TG) is an uncommon pediatric low-grade tumor with limited data on long-term outcome. A retrospective review of TG diagnosed in patients ≤ 21 years at our center between 1986 and 2013 identified 19 patients (males=13; median age at diagnosis=10 years [yrs]; range, 0.01-19.99). All patients were diagnosed based on MRI. Initial CSF diversion was necessary in 16 patients (ventriculoperitoneal [VP] shunt= 10; endoscopic third ventriculostomy=6). Ommaya reservoir was inserted in 5 patients. VP shunt revisions (1-12 times) were required in 7 patients; while 2 patients had subdural hematoma due to over-shunting. Biopsy or resection was performed in 7 patients (upfront=5, at progression=2), with histology showing pilocytic astrocytoma (n=6) or low-grade glioma, NOS (n=1). Duplication of chromosome 7q34, marker of KIAA1549-BRAF fusion, was detected in 2 of 4 patients tested. Adjuvant therapy was delivered in 8 patients mostly upon progression, and included focal radiation (n=4), systemic therapy (n=3), or a combination (n=1). The median duration of follow-up was 9.57 yrs (range, 3.64-16.98): 7 experienced progression at median of 0.68 yrs (range, 0.28-8.98), including 2 with metastases. One patient each died due to suicide, obstructive hydrocephalus, and suspected shunt malfunction. Respective 5- and 10yr overall-survival were 92.9 ± 6.9% and 85.1 ± 9.7%. Long-term morbidities included persistent headache (n=8) and visual symptoms (n=7). Significant impairments were seen on measures of intelligence (n=2/9; 22%), working memory (n=2/7; 29%), and processing speed (n=6/6; 100%). Long-term survival of children with TG is satisfactory. Regular follow-up is recommended due to risks of shunt failure, progression, and long-term morbidities.
Descriptionposter presentation
Persistent Identifierhttp://hdl.handle.net/10722/265283
ISSN
2019 Impact Factor: 10.247
2015 SCImago Journal Rankings: 3.196

 

DC FieldValueLanguage
dc.contributor.authorLiu, APY-
dc.contributor.authorHarreld, J-
dc.contributor.authorJacola, L-
dc.contributor.authorGero, M-
dc.contributor.authorAcharya, S-
dc.contributor.authorChiang, J-
dc.contributor.authorGhazwani, Y-
dc.contributor.authorWu, S-
dc.contributor.authorKlimo Jr., P-
dc.contributor.authorGajjar, A-
dc.contributor.authorQaddoumi, I-
dc.date.accessioned2018-11-20T02:03:37Z-
dc.date.available2018-11-20T02:03:37Z-
dc.date.issued2018-
dc.identifier.citationThe 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) , Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i108–i109, article no. LGG-21-
dc.identifier.issn1522-8517-
dc.identifier.urihttp://hdl.handle.net/10722/265283-
dc.descriptionposter presentation-
dc.description.abstractTectal glioma (TG) is an uncommon pediatric low-grade tumor with limited data on long-term outcome. A retrospective review of TG diagnosed in patients ≤ 21 years at our center between 1986 and 2013 identified 19 patients (males=13; median age at diagnosis=10 years [yrs]; range, 0.01-19.99). All patients were diagnosed based on MRI. Initial CSF diversion was necessary in 16 patients (ventriculoperitoneal [VP] shunt= 10; endoscopic third ventriculostomy=6). Ommaya reservoir was inserted in 5 patients. VP shunt revisions (1-12 times) were required in 7 patients; while 2 patients had subdural hematoma due to over-shunting. Biopsy or resection was performed in 7 patients (upfront=5, at progression=2), with histology showing pilocytic astrocytoma (n=6) or low-grade glioma, NOS (n=1). Duplication of chromosome 7q34, marker of KIAA1549-BRAF fusion, was detected in 2 of 4 patients tested. Adjuvant therapy was delivered in 8 patients mostly upon progression, and included focal radiation (n=4), systemic therapy (n=3), or a combination (n=1). The median duration of follow-up was 9.57 yrs (range, 3.64-16.98): 7 experienced progression at median of 0.68 yrs (range, 0.28-8.98), including 2 with metastases. One patient each died due to suicide, obstructive hydrocephalus, and suspected shunt malfunction. Respective 5- and 10yr overall-survival were 92.9 ± 6.9% and 85.1 ± 9.7%. Long-term morbidities included persistent headache (n=8) and visual symptoms (n=7). Significant impairments were seen on measures of intelligence (n=2/9; 22%), working memory (n=2/7; 29%), and processing speed (n=6/6; 100%). Long-term survival of children with TG is satisfactory. Regular follow-up is recommended due to risks of shunt failure, progression, and long-term morbidities.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org-
dc.relation.ispartofNeuro-Oncology-
dc.relation.ispartofThe 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018)-
dc.subjectmagnetic resonance imaging-
dc.subjecthematoma-
dc.subjectsubdural-
dc.subjectbiopsy-
dc.subjectendoscopy-
dc.titleLong-term outcome of patients with pediatric tectal glioma-
dc.typeConference_Paper-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.authorityLiu, APY=rp01357-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/neuonc/noy059.362-
dc.identifier.hkuros295914-
dc.identifier.hkuros315014-
dc.identifier.volume20-
dc.identifier.issueSuppl. 2-
dc.identifier.spagei108-
dc.identifier.epagei109-
dc.publisher.placeUnited States-

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