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Article: Breast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings

TitleBreast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings
Authors
Issue Date2019
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2474-9842
Citation
BJS Open, 2019, v. 3 n. 1, p. 48-55 How to Cite?
AbstractBackground: Mastectomy rates among women with early breast cancer in Asia have traditionally been high. This study assessed trends in the surgical management of young women with early‐stage breast cancer in Asian settings. Survival in women treated with breast‐conserving surgery (BCS; lumpectomy with adjuvant radiotherapy) and those undergoing mastectomy was compared. Methods: Young women (aged less than 50 years) newly diagnosed with stage I or II (T1–2 N0–1 M0) breast cancer in four hospitals in Malaysia, Singapore and Hong Kong in 1990–2012 were included. Overall survival (OS) was compared for patients treated by BCS and those who had a mastectomy. Propensity score analysis was used to account for differences in demographic, tumour and treatment characteristics between the groups. Results: Some 63·5 per cent of 3536 women underwent mastectomy. Over a 15‐year period, only a modest increase in rates of BCS was observed. Although BCS was significantly associated with favourable prognostic features, OS was not significantly different for BCS and mastectomy; the 5‐year OS rate was 94·9 (95 per cent c.i. 93·5 to 96·3) and 92·9 (91·7 to 94·1) per cent respectively. Inferences remained unchanged following propensity score analysis (hazard ratio for BCS versus mastectomy: 0·81, 95 per cent c.i. 0·64 to 1·03). Conclusion: The prevalence of young women with breast cancer treated by mastectomy remains high in Asian countries. Patients treated with BCS appear to survive as well as those undergoing mastectomy.
Persistent Identifierhttp://hdl.handle.net/10722/265151
ISSN
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSinnadurai, S-
dc.contributor.authorKwong, A-
dc.contributor.authorHartman, M-
dc.contributor.authorTan, EY-
dc.contributor.authorBhoo-Pathy, NT-
dc.contributor.authorDahlui, M-
dc.contributor.authorSee, MH-
dc.contributor.authorYip, CH-
dc.contributor.authorTaib, NA-
dc.contributor.authorBhoo-Pathy, N-
dc.date.accessioned2018-11-20T02:01:10Z-
dc.date.available2018-11-20T02:01:10Z-
dc.date.issued2019-
dc.identifier.citationBJS Open, 2019, v. 3 n. 1, p. 48-55-
dc.identifier.issn2474-9842-
dc.identifier.urihttp://hdl.handle.net/10722/265151-
dc.description.abstractBackground: Mastectomy rates among women with early breast cancer in Asia have traditionally been high. This study assessed trends in the surgical management of young women with early‐stage breast cancer in Asian settings. Survival in women treated with breast‐conserving surgery (BCS; lumpectomy with adjuvant radiotherapy) and those undergoing mastectomy was compared. Methods: Young women (aged less than 50 years) newly diagnosed with stage I or II (T1–2 N0–1 M0) breast cancer in four hospitals in Malaysia, Singapore and Hong Kong in 1990–2012 were included. Overall survival (OS) was compared for patients treated by BCS and those who had a mastectomy. Propensity score analysis was used to account for differences in demographic, tumour and treatment characteristics between the groups. Results: Some 63·5 per cent of 3536 women underwent mastectomy. Over a 15‐year period, only a modest increase in rates of BCS was observed. Although BCS was significantly associated with favourable prognostic features, OS was not significantly different for BCS and mastectomy; the 5‐year OS rate was 94·9 (95 per cent c.i. 93·5 to 96·3) and 92·9 (91·7 to 94·1) per cent respectively. Inferences remained unchanged following propensity score analysis (hazard ratio for BCS versus mastectomy: 0·81, 95 per cent c.i. 0·64 to 1·03). Conclusion: The prevalence of young women with breast cancer treated by mastectomy remains high in Asian countries. Patients treated with BCS appear to survive as well as those undergoing mastectomy.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2474-9842-
dc.relation.ispartofBJS Open-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleBreast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/bjs5.50111-
dc.identifier.pmid30734015-
dc.identifier.pmcidPMC6354186-
dc.identifier.hkuros295921-
dc.identifier.volume3-
dc.identifier.issue1-
dc.identifier.spage48-
dc.identifier.epage55-
dc.identifier.isiWOS:000457222900006-
dc.publisher.placeUnited Kingdom-

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