File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Application of Flash Nanoprecipitation to Fabricate Poorly Water-soluble Drug Nanoparticles

TitleApplication of Flash Nanoprecipitation to Fabricate Poorly Water-soluble Drug Nanoparticles
Authors
KeywordsPoorly water-soluble drug
Flash nanoprecipitation
Microfluidic mixer device
Nanoparticles
Issue Date2019
PublisherElsevier. The Journal's web site is located at http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b
Citation
Acta Pharmaceutica Sinica B, 2019, v. 9 n. 1, p. 4-18 How to Cite?
AbstractNanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles, polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer (CIJM), multi-inlet vortex mixer (MIVM) and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly water-soluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up.
Persistent Identifierhttp://hdl.handle.net/10722/265114
ISSN
2017 Impact Factor: 6.014
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTao, J-
dc.contributor.authorChow, SF-
dc.contributor.authorZheng, Y-
dc.date.accessioned2018-11-20T02:00:28Z-
dc.date.available2018-11-20T02:00:28Z-
dc.date.issued2019-
dc.identifier.citationActa Pharmaceutica Sinica B, 2019, v. 9 n. 1, p. 4-18-
dc.identifier.issn2211-3835-
dc.identifier.urihttp://hdl.handle.net/10722/265114-
dc.description.abstractNanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles, polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer (CIJM), multi-inlet vortex mixer (MIVM) and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly water-soluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up.-
dc.languageeng-
dc.publisherElsevier. The Journal's web site is located at http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b-
dc.relation.ispartofActa Pharmaceutica Sinica B-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPoorly water-soluble drug-
dc.subjectFlash nanoprecipitation-
dc.subjectMicrofluidic mixer device-
dc.subjectNanoparticles-
dc.titleApplication of Flash Nanoprecipitation to Fabricate Poorly Water-soluble Drug Nanoparticles-
dc.typeArticle-
dc.identifier.emailChow, SF: asfchow@hku.hk-
dc.identifier.authorityChow, SF=rp02296-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.apsb.2018.11.001-
dc.identifier.scopuseid_2-s2.0-85058684367-
dc.identifier.hkuros296222-
dc.identifier.hkuros297423-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.spage4-
dc.identifier.epage18-
dc.identifier.isiWOS:000457201700002-
dc.publisher.placeChina-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats