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Article: The impact of host genetic diversity on virus evolution and emergence

TitleThe impact of host genetic diversity on virus evolution and emergence
Authors
Issue Date2018
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1461-0248
Citation
Ecology Letters, 2018, v. 21, p. 253-263 How to Cite?
AbstractAccumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. The vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. Although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite emergence, this effect has seldom been tested empirically. Using Rabies virus (RABV) as a model parasite, we provide evidence that greater host genetic diversity increases both parasite genetic diversity and the likelihood of a host being a donor in RABV cross-species transmission events. We conclude that host genetic diversity may be an important determinant of parasite evolution and emergence.
Persistent Identifierhttp://hdl.handle.net/10722/263776
ISSN
2017 Impact Factor: 9.137
2015 SCImago Journal Rankings: 8.630
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRodríguez-Nevado, C-
dc.contributor.authorLam, TY-
dc.contributor.authorHolmes, EC-
dc.contributor.authorPagán, I-
dc.date.accessioned2018-10-22T07:44:18Z-
dc.date.available2018-10-22T07:44:18Z-
dc.date.issued2018-
dc.identifier.citationEcology Letters, 2018, v. 21, p. 253-263-
dc.identifier.issn1461-023X-
dc.identifier.urihttp://hdl.handle.net/10722/263776-
dc.description.abstractAccumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. The vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. Although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite emergence, this effect has seldom been tested empirically. Using Rabies virus (RABV) as a model parasite, we provide evidence that greater host genetic diversity increases both parasite genetic diversity and the likelihood of a host being a donor in RABV cross-species transmission events. We conclude that host genetic diversity may be an important determinant of parasite evolution and emergence.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1461-0248-
dc.relation.ispartofEcology Letters-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article].-
dc.titleThe impact of host genetic diversity on virus evolution and emergence-
dc.typeArticle-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.authorityLam, TY=rp01733-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/ele.12890-
dc.identifier.hkuros294134-
dc.identifier.volume21-
dc.identifier.spage253-
dc.identifier.epage263-
dc.identifier.isiWOS:000425823900011-
dc.publisher.placeUnited Kingdom-

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