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- Publisher Website: 10.1007/s40843-016-5152-2
- Scopus: eid_2-s2.0-85035030349
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Article: The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy
Title | The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy 基于AFM的化疗药物与质粒DNA间动态相互作用观测 |
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Authors | |
Keywords | atomic force microscopy cisplatin drug methotrexate plasmid DNA |
Issue Date | 2017 |
Publisher | Springer Verlag, co-published with Science China Press. The Journal's web site is located at https://link.springer.com/journal/40843 |
Citation | Science China Materials, 2017, v. 60, p. 269-278 How to Cite? |
Abstract | The advent of atomic force microscopy (AFM) provides a powerful tool for imaging individual DNA molecules. Chemotherapy drugs are often related to DNAs. Though many specific drug-DNA interactions have been observed by AFM, knowledge about the dynamic interactions between chemotherapy drugs and plasmid DNAs is still scarce. In this work, AFM was applied to investigate the nanoscale interactions between plasmid DNAs and two commercial chemotherapy drugs (methotrexate and cisplatin). Plasmid DNAs were immobilized on mica which was coated by silanes in advance. AFM imaging distinctly revealed the dynamic changes of single plasmid DNAs after the stimulation of methotrexate and cisplatin. Geometric features of plasmid DNAs were extracted from AFM images and the statistical results showed that the geometric features of plasmid DNAs changed significantly after the stimulation of drugs. This research provides a novel idea to study the actions of chemotherapy drugs against plasmid DNAs at the single-molecule level. |
Persistent Identifier | http://hdl.handle.net/10722/261780 |
ISSN | 2021 Impact Factor: 8.640 2020 SCImago Journal Rankings: 1.504 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, M | - |
dc.contributor.author | Liu, L | - |
dc.contributor.author | Xiao, X | - |
dc.contributor.author | Xi, N | - |
dc.contributor.author | Wang, Y | - |
dc.date.accessioned | 2018-09-28T04:47:45Z | - |
dc.date.available | 2018-09-28T04:47:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Science China Materials, 2017, v. 60, p. 269-278 | - |
dc.identifier.issn | 2095-8226 | - |
dc.identifier.uri | http://hdl.handle.net/10722/261780 | - |
dc.description.abstract | The advent of atomic force microscopy (AFM) provides a powerful tool for imaging individual DNA molecules. Chemotherapy drugs are often related to DNAs. Though many specific drug-DNA interactions have been observed by AFM, knowledge about the dynamic interactions between chemotherapy drugs and plasmid DNAs is still scarce. In this work, AFM was applied to investigate the nanoscale interactions between plasmid DNAs and two commercial chemotherapy drugs (methotrexate and cisplatin). Plasmid DNAs were immobilized on mica which was coated by silanes in advance. AFM imaging distinctly revealed the dynamic changes of single plasmid DNAs after the stimulation of methotrexate and cisplatin. Geometric features of plasmid DNAs were extracted from AFM images and the statistical results showed that the geometric features of plasmid DNAs changed significantly after the stimulation of drugs. This research provides a novel idea to study the actions of chemotherapy drugs against plasmid DNAs at the single-molecule level. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag, co-published with Science China Press. The Journal's web site is located at https://link.springer.com/journal/40843 | - |
dc.relation.ispartof | Science China Materials | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/[insert DOI] | - |
dc.subject | atomic force microscopy | - |
dc.subject | cisplatin | - |
dc.subject | drug | - |
dc.subject | methotrexate | - |
dc.subject | plasmid DNA | - |
dc.title | The dynamic interactions between chemotherapy drugs and plasmid DNA investigated by atomic force microscopy | - |
dc.title | 基于AFM的化疗药物与质粒DNA间动态相互作用观测 | - |
dc.type | Article | - |
dc.identifier.email | Xi, N: xining@hku.hk | - |
dc.identifier.authority | Xi, N=rp02044 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1007/s40843-016-5152-2 | - |
dc.identifier.scopus | eid_2-s2.0-85035030349 | - |
dc.identifier.hkuros | 292799 | - |
dc.identifier.volume | 60 | - |
dc.identifier.spage | 269 | - |
dc.identifier.epage | 278 | - |
dc.identifier.isi | WOS:000398129000008 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 2095-8226 | - |