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Article: A Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy

TitleA Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy
Authors
Issue Date2018
PublisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7729
Citation
IEEE Transactions on Nanotechnology, 2018, v. 17, p. 920-933 How to Cite?
AbstractDeoxyribonucleic acid (DNA), the structural basis of genetics, plays a crucial role in the life of cells. The abnormal behaviors of DNA are closely related to the pathological changes of living organisms. The advent of atomic force microscopy (AFM) provides an exciting instrument for biophysically probing the nanoscale dynamic activities of the individual native molecules, considerably complementing the results obtained by traditional biochemical population-averaged measurements. In the past decades, AFM has been widely used in DNA studies, significantly providing novel insights into molecular biology. In this paper, the methodologies and progresses of utilizing AFM to characterize the behaviors of individual DNA molecules from several facets (including DNA topography imaging, DNA mechanics measurements, DNA origami, and DNA nanorobotics) are reviewed, and the future directions are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/261772
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, M-
dc.contributor.authorDang, D-
dc.contributor.authorXi, N-
dc.contributor.authorWang, Y-
dc.contributor.authorLiu, L-
dc.date.accessioned2018-09-28T04:47:36Z-
dc.date.available2018-09-28T04:47:36Z-
dc.date.issued2018-
dc.identifier.citationIEEE Transactions on Nanotechnology, 2018, v. 17, p. 920-933-
dc.identifier.urihttp://hdl.handle.net/10722/261772-
dc.description.abstractDeoxyribonucleic acid (DNA), the structural basis of genetics, plays a crucial role in the life of cells. The abnormal behaviors of DNA are closely related to the pathological changes of living organisms. The advent of atomic force microscopy (AFM) provides an exciting instrument for biophysically probing the nanoscale dynamic activities of the individual native molecules, considerably complementing the results obtained by traditional biochemical population-averaged measurements. In the past decades, AFM has been widely used in DNA studies, significantly providing novel insights into molecular biology. In this paper, the methodologies and progresses of utilizing AFM to characterize the behaviors of individual DNA molecules from several facets (including DNA topography imaging, DNA mechanics measurements, DNA origami, and DNA nanorobotics) are reviewed, and the future directions are discussed.-
dc.languageeng-
dc.publisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7729-
dc.relation.ispartofIEEE Transactions on Nanotechnology-
dc.rightsIEEE Transactions on Nanotechnology. Copyright © IEEE.-
dc.rights©20xx IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. -
dc.titleA Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy-
dc.typeArticle-
dc.identifier.emailXi, N: xining@hku.hk-
dc.identifier.authorityXi, N=rp02044-
dc.identifier.doi10.1109/TNANO.2018.2821164-
dc.identifier.hkuros292486-
dc.identifier.volume17-
dc.identifier.spage920-
dc.identifier.epage933-
dc.identifier.isiWOS:000443975800008-

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