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Conference Paper: Modeling and analysis of living beating cardiomyocyte in sub-cell scale

TitleModeling and analysis of living beating cardiomyocyte in sub-cell scale
Authors
Issue Date2017
PublisherIEEE. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000487
Citation
Proeedings of 2017 IEEE 17th International Conference on Nanotechnology (IEEE-NANO), Pittsburgh, PA, USA, 25-28 July 2017, p. 406-410 How to Cite?
AbstractThe research on heart cells have attracted broad attention for the development of either heart disease therapy or muscle cell-based actuation for bio-syncretic robots. In order to study the mechanism and dynamics of beating activity of cardiomyocytes, many research methods have been proposed, such as the measurement of contractility and action potential of the cells. However, few of them has focused on the effect from the mechanical properties of sub-cell elements on the contraction performance of heart cells. In this work, a mechanical model of single heart cell was proposed based on the sub-cell structures, to study and control the contraction of the cardiomyocytes. The parameters of the parts in the theoretical model were identified with the cellular beating data obtained using Scanning Ion Conductance Microscopy (SICM) based on the derived mathematic model. Therefore, the contraction performance and the mechanical properties of sub-cell elements associated with the mechanical properties of parts in the model can be obtained for the further analysis of the relationship between the cell activity and sub-cell structures. This work is fundamental and meaningful for the research on cytobiology, heart mechanism and bio-syncretic robotics.
Persistent Identifierhttp://hdl.handle.net/10722/261614

 

DC FieldValueLanguage
dc.contributor.authorZhang, C-
dc.contributor.authorWang, W-
dc.contributor.authorXi, N-
dc.contributor.authorWang, Y-
dc.contributor.authorLiu, L-
dc.date.accessioned2018-09-28T04:44:42Z-
dc.date.available2018-09-28T04:44:42Z-
dc.date.issued2017-
dc.identifier.citationProeedings of 2017 IEEE 17th International Conference on Nanotechnology (IEEE-NANO), Pittsburgh, PA, USA, 25-28 July 2017, p. 406-410-
dc.identifier.urihttp://hdl.handle.net/10722/261614-
dc.description.abstractThe research on heart cells have attracted broad attention for the development of either heart disease therapy or muscle cell-based actuation for bio-syncretic robots. In order to study the mechanism and dynamics of beating activity of cardiomyocytes, many research methods have been proposed, such as the measurement of contractility and action potential of the cells. However, few of them has focused on the effect from the mechanical properties of sub-cell elements on the contraction performance of heart cells. In this work, a mechanical model of single heart cell was proposed based on the sub-cell structures, to study and control the contraction of the cardiomyocytes. The parameters of the parts in the theoretical model were identified with the cellular beating data obtained using Scanning Ion Conductance Microscopy (SICM) based on the derived mathematic model. Therefore, the contraction performance and the mechanical properties of sub-cell elements associated with the mechanical properties of parts in the model can be obtained for the further analysis of the relationship between the cell activity and sub-cell structures. This work is fundamental and meaningful for the research on cytobiology, heart mechanism and bio-syncretic robotics.-
dc.languageeng-
dc.publisherIEEE. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000487-
dc.relation.ispartof2017 IEEE 17th International Conference on Nanotechnology (IEEE-NANO)-
dc.rightsIEEE International Conference on Nanotechnology (IEEE-NANO). Copyright © IEEE.-
dc.rights©2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.-
dc.titleModeling and analysis of living beating cardiomyocyte in sub-cell scale-
dc.typeConference_Paper-
dc.identifier.emailXi, N: xining@hku.hk-
dc.identifier.authorityXi, N=rp02044-
dc.identifier.doi10.1109/NANO.2017.8117268-
dc.identifier.hkuros292790-
dc.identifier.spage406-
dc.identifier.epage410-
dc.publisher.placeUnited States-

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