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Article: Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study

TitleSerum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study
Authors
KeywordsAssociation
Diabetes
Follicle stimulating hormone (FSH)
Menopause
Issue Date2018
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas
Citation
Maturitas, 2018, v. 114, p. 41-45 How to Cite?
AbstractMenopause is an important transition of reproductive stage in a woman's life. It is associated with diabetes, but the role of follicle stimulating hormone (FSH), a menopause-related hormone, in the risk of diabetes is largely unknown. We evaluated the relationship between serum FSH and diabetes in 1274 participants from the Hong Kong Osteoporosis Study aged≥55 at baseline. We also searched relevant databases for studies on serum FSH and incident diabetes and conducted a meta-analysis using fixed-effect modeling. Cases of incident diabetes (N = 60) were ascertained during a median follow-up of 10.7 years. Serum FSH was significantly associated with reduced risk of diabetes in both a crude model (hazard ratio [HR] per SD increase: 0.66; 95% CI: 0.48-0.89; P = 0.007) and a full model with adjustment for age, sex, body mass index, factors related to risk of diabetes, and reproductive health (HR per SD increase: 0.70; 95% CI: 0.51-0.97; P = 0.030); a similar result was observed when FSH was analysed in quintiles. In a fixed-effect meta-analysis of two studies, including the current study, serum FSH > 50 IU/L was associated with reduced risk of diabetes (HR = 0.56; 95% CI: 0.36-0.85; P = 0.006; I2 = 0). In conclusion, serum FSH levels were independently associated with diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/260524
ISSN
2017 Impact Factor: 3.315
2015 SCImago Journal Rankings: 1.107

 

DC FieldValueLanguage
dc.contributor.authorCheung, CL-
dc.contributor.authorKung, AWC-
dc.contributor.authorTan, KCB-
dc.date.accessioned2018-09-14T08:43:06Z-
dc.date.available2018-09-14T08:43:06Z-
dc.date.issued2018-
dc.identifier.citationMaturitas, 2018, v. 114, p. 41-45-
dc.identifier.issn0378-5122-
dc.identifier.urihttp://hdl.handle.net/10722/260524-
dc.description.abstractMenopause is an important transition of reproductive stage in a woman's life. It is associated with diabetes, but the role of follicle stimulating hormone (FSH), a menopause-related hormone, in the risk of diabetes is largely unknown. We evaluated the relationship between serum FSH and diabetes in 1274 participants from the Hong Kong Osteoporosis Study aged≥55 at baseline. We also searched relevant databases for studies on serum FSH and incident diabetes and conducted a meta-analysis using fixed-effect modeling. Cases of incident diabetes (N = 60) were ascertained during a median follow-up of 10.7 years. Serum FSH was significantly associated with reduced risk of diabetes in both a crude model (hazard ratio [HR] per SD increase: 0.66; 95% CI: 0.48-0.89; P = 0.007) and a full model with adjustment for age, sex, body mass index, factors related to risk of diabetes, and reproductive health (HR per SD increase: 0.70; 95% CI: 0.51-0.97; P = 0.030); a similar result was observed when FSH was analysed in quintiles. In a fixed-effect meta-analysis of two studies, including the current study, serum FSH > 50 IU/L was associated with reduced risk of diabetes (HR = 0.56; 95% CI: 0.36-0.85; P = 0.006; I2 = 0). In conclusion, serum FSH levels were independently associated with diabetes.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas-
dc.relation.ispartofMaturitas-
dc.subjectAssociation-
dc.subjectDiabetes-
dc.subjectFollicle stimulating hormone (FSH)-
dc.subjectMenopause-
dc.titleSerum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women: The Hong Kong osteoporosis study-
dc.typeArticle-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.emailKung, AWC: awckung@hku.hk-
dc.identifier.emailTan, KCB: kcbtan@hkucc.hku.hk-
dc.identifier.authorityCheung, CL=rp01749-
dc.identifier.authorityKung, AWC=rp00368-
dc.identifier.authorityTan, KCB=rp00402-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.maturitas.2018.05.011-
dc.identifier.pmid29907245-
dc.identifier.scopuseid_2-s2.0-85047870400-
dc.identifier.hkuros290697-
dc.identifier.volume114-
dc.identifier.spage41-
dc.identifier.epage45-
dc.publisher.placeIreland-

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