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Article: Optogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response

TitleOptogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response
Authors
Issue Date2018
PublisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2018, v. 8, p. 8736 How to Cite?
AbstractSensory cortices contain extensive descending (corticofugal) pathways, yet their impact on brainstem processing - particularly across sensory systems - remains poorly understood. In the auditory system, the inferior colliculus (IC) in the midbrain receives cross-modal inputs from the visual cortex (VC). However, the influences from VC on auditory midbrain processing are unclear. To investigate whether and how visual cortical inputs affect IC auditory responses, the present study combines auditory blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) with cell-type specific optogenetic manipulation of visual cortex. The results show that predominant optogenetic excitation of the excitatory pyramidal neurons in the infragranular layers of the primary VC enhances the noise-evoked BOLD fMRI responses within the IC. This finding reveals that inputs from VC influence and facilitate basic sound processing in the auditory midbrain. Such combined optogenetic and auditory fMRI approach can shed light on the large-scale modulatory effects of corticofugal pathways and guide detailed electrophysiological studies in the future.
Persistent Identifierhttp://hdl.handle.net/10722/260445
ISSN
2017 Impact Factor: 4.122
2015 SCImago Journal Rankings: 2.073
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeong, TL-
dc.contributor.authorDong, M-
dc.contributor.authorGao, P-
dc.contributor.authorChan, RW-
dc.contributor.authorTo, KWA-
dc.contributor.authorSanes, DH-
dc.contributor.authorWu, EX-
dc.date.accessioned2018-09-14T08:41:50Z-
dc.date.available2018-09-14T08:41:50Z-
dc.date.issued2018-
dc.identifier.citationScientific Reports, 2018, v. 8, p. 8736-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/260445-
dc.description.abstractSensory cortices contain extensive descending (corticofugal) pathways, yet their impact on brainstem processing - particularly across sensory systems - remains poorly understood. In the auditory system, the inferior colliculus (IC) in the midbrain receives cross-modal inputs from the visual cortex (VC). However, the influences from VC on auditory midbrain processing are unclear. To investigate whether and how visual cortical inputs affect IC auditory responses, the present study combines auditory blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) with cell-type specific optogenetic manipulation of visual cortex. The results show that predominant optogenetic excitation of the excitatory pyramidal neurons in the infragranular layers of the primary VC enhances the noise-evoked BOLD fMRI responses within the IC. This finding reveals that inputs from VC influence and facilitate basic sound processing in the auditory midbrain. Such combined optogenetic and auditory fMRI approach can shed light on the large-scale modulatory effects of corticofugal pathways and guide detailed electrophysiological studies in the future.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleOptogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response-
dc.typeArticle-
dc.identifier.emailLeong, TL: tlleong@hku.hk-
dc.identifier.emailTo, KWA: toanthea@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-018-26568-1-
dc.identifier.scopuseid_2-s2.0-85048237116-
dc.identifier.hkuros291491-
dc.identifier.volume8-
dc.identifier.spage8736-
dc.identifier.epage8736-
dc.identifier.isiWOS:000434376700038-
dc.publisher.placeUnited Kingdom-

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