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Article: Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils

TitleBudding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils
Authors
Issue Date2018
Citation
Nature Communications, 2018, v. 9 How to Cite?
AbstractNetworks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of all-aqueous emulsion droplets with budding-like morphologies. We show that this process is driven by the difference in the immersional wetting energy of the nanofibril network, and that both the size and the number of the daughter droplets formed during division can be controlled by modulating the fibril concentration and the chemical properties of the fibril network. Our results demonstrate a route for achieving biomimetic division with synthetic self-assembling fibrils and offer an engineered approach to regulate the morphology of protein gels.
Persistent Identifierhttp://hdl.handle.net/10722/260323
ISSN
2015 Impact Factor: 11.329
2015 SCImago Journal Rankings: 6.539

 

DC FieldValueLanguage
dc.contributor.authorSong, Y-
dc.contributor.authorMichaels, TCT-
dc.contributor.authorMa, QM-
dc.contributor.authorLiu, Z-
dc.contributor.authorYuan, H-
dc.contributor.authorTakayama, S-
dc.contributor.authorKnowles, TPJ-
dc.contributor.authorShum, HC-
dc.date.accessioned2018-09-14T08:39:45Z-
dc.date.available2018-09-14T08:39:45Z-
dc.date.issued2018-
dc.identifier.citationNature Communications, 2018, v. 9-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/260323-
dc.description.abstractNetworks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of all-aqueous emulsion droplets with budding-like morphologies. We show that this process is driven by the difference in the immersional wetting energy of the nanofibril network, and that both the size and the number of the daughter droplets formed during division can be controlled by modulating the fibril concentration and the chemical properties of the fibril network. Our results demonstrate a route for achieving biomimetic division with synthetic self-assembling fibrils and offer an engineered approach to regulate the morphology of protein gels.-
dc.languageeng-
dc.relation.ispartofNature Communications-
dc.titleBudding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils-
dc.typeArticle-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.identifier.doi10.1038/s41467-018-04510-3-
dc.identifier.hkuros290227-
dc.identifier.volume9-

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