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Article: Ultrasensitive Phototriggered Local Anesthesia

TitleUltrasensitive Phototriggered Local Anesthesia
Authors
Keywordsgold nanorod
liposome
local anesthesia
Phototriggering
tetrodotoxin
Issue Date2017
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett
Citation
Nano Letters, 2017, v. 17 n. 2, p. 660-665 How to Cite?
AbstractAn injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1–2 min of irradiation at ≤272 mW/cm2 produced repeatable and adjustable on-demand infiltration anesthesia or sciatic nerve blockade with minimal toxicity. The nerve block intensity and duration correlated with the irradiance and duration of the applied light.
Persistent Identifierhttp://hdl.handle.net/10722/260282
ISSN
2015 Impact Factor: 13.779
2015 SCImago Journal Rankings: 9.006

 

DC FieldValueLanguage
dc.contributor.authorZhan, CY-
dc.contributor.authorWang, W-
dc.contributor.authorSantamaria, C-
dc.contributor.authorWang, B-
dc.contributor.authorRwei, A-
dc.contributor.authorTimko, BP-
dc.contributor.authorKohane, DS-
dc.date.accessioned2018-09-12T07:37:12Z-
dc.date.available2018-09-12T07:37:12Z-
dc.date.issued2017-
dc.identifier.citationNano Letters, 2017, v. 17 n. 2, p. 660-665-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/260282-
dc.description.abstractAn injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1–2 min of irradiation at ≤272 mW/cm2 produced repeatable and adjustable on-demand infiltration anesthesia or sciatic nerve blockade with minimal toxicity. The nerve block intensity and duration correlated with the irradiance and duration of the applied light.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett-
dc.relation.ispartofNano Letters-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectgold nanorod-
dc.subjectliposome-
dc.subjectlocal anesthesia-
dc.subjectPhototriggering-
dc.subjecttetrodotoxin-
dc.titleUltrasensitive Phototriggered Local Anesthesia-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.identifier.doi10.1021/acs.nanolett.6b03588-
dc.identifier.volume17-
dc.identifier.issue2-
dc.identifier.spage660-
dc.identifier.epage665-
dc.publisher.placeUnited States-

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