File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals

TitleFTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals
Authors
Qi, QibinKilpeläinen, Tuomas O.Downer, Mary K.Tanaka, ToshikoSmith, Caren E.Sluijs, IvonneSonestedt, EmilyChu, Audrey Y.Renström, FridaLin, XiaochenÄngquist, Lars H.Huang, JinyanLiu, ZhonghuaLi, YanpingAsif Ali, MuhammadXu, MinAhluwalia, Tarunveer S.inghBoer, Jolanda M.A.Chen, PengDaimon, MakotoEriksson, JohanPerola, MarkusFriedlander, YechielGao, Yu TangHeppe, Denise H.M.Holloway, John W.Houston, Denise K.Kanoni, StavroulaKim, Yu MiLaaksonen, Maarit A.Jääskeläinen, TiinaLee, Nanette R.Lehtimäki, TerhoLemaitre, Rozenn N.Lu, WeiLuben, Robert N.Manichaikul, AniMännistö, SatuMarques-Vidal, PedroMonda, Keri L.Ngwa, Julius S.Perusse, Louisvan Rooij, Frank J.A.Xiang, Yong BingWen, WanqingWojczynski, Mary K.Zhu, JingwenBorecki, Ingrid B.Bouchard, ClaudeCai, QiuyinCooper, CyrusDedoussis, George V.Deloukas, PanosFerrucci, LuigiForouhi, Nita G.Hansen, TorbenChristiansen, LeneHofman, AlbertJohansson, IngegerdJørgensen, TorbenKarasawa, ShigeruKhaw, Kay TeeKim, Mi KyungKristiansson, KatiLi, HuaixingLin, XuLiu, YongmeiLohman, Kurt K.Long, JirongMikkilä, VeraMozaffarian, DariushNorth, KariPedersen, OlufRaitakari, OlliRissanen, HarriTuomilehto, Jaakkovan der Schouw, Yvonne T.Uitterlinden, André G.Zillikens, M. CarolaFranco, Oscar H.Shyong Tai, E.Ou Shu, XiaoSiscovick, David S.Toft, UllaVerschuren, W. M.MoniqueVollenweider, PeterWareham, Nicholas J.Witteman, Jacqueline C.M.Zheng, WeiRidker, Paul M.Kang, Jae H.Liang, LimingJensen, Majken K.Curhan, Gary C.Pasquale, Louis R.Hunter, David J.Mohlke, Karen L.Uusitupa, MattiCupples, L. AdrienneRankinen, Tuomo
Issue Date2014
Citation
Human molecular genetics, 2014, v. 23, n. 25, p. 6961-6972 How to Cite?
Abstract© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177,330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
Persistent Identifierhttp://hdl.handle.net/10722/260210

 

DC FieldValueLanguage
dc.contributor.authorQi, Qibin-
dc.contributor.authorKilpeläinen, Tuomas O.-
dc.contributor.authorDowner, Mary K.-
dc.contributor.authorTanaka, Toshiko-
dc.contributor.authorSmith, Caren E.-
dc.contributor.authorSluijs, Ivonne-
dc.contributor.authorSonestedt, Emily-
dc.contributor.authorChu, Audrey Y.-
dc.contributor.authorRenström, Frida-
dc.contributor.authorLin, Xiaochen-
dc.contributor.authorÄngquist, Lars H.-
dc.contributor.authorHuang, Jinyan-
dc.contributor.authorLiu, Zhonghua-
dc.contributor.authorLi, Yanping-
dc.contributor.authorAsif Ali, Muhammad-
dc.contributor.authorXu, Min-
dc.contributor.authorAhluwalia, Tarunveer S.ingh-
dc.contributor.authorBoer, Jolanda M.A.-
dc.contributor.authorChen, Peng-
dc.contributor.authorDaimon, Makoto-
dc.contributor.authorEriksson, Johan-
dc.contributor.authorPerola, Markus-
dc.contributor.authorFriedlander, Yechiel-
dc.contributor.authorGao, Yu Tang-
dc.contributor.authorHeppe, Denise H.M.-
dc.contributor.authorHolloway, John W.-
dc.contributor.authorHouston, Denise K.-
dc.contributor.authorKanoni, Stavroula-
dc.contributor.authorKim, Yu Mi-
dc.contributor.authorLaaksonen, Maarit A.-
dc.contributor.authorJääskeläinen, Tiina-
dc.contributor.authorLee, Nanette R.-
dc.contributor.authorLehtimäki, Terho-
dc.contributor.authorLemaitre, Rozenn N.-
dc.contributor.authorLu, Wei-
dc.contributor.authorLuben, Robert N.-
dc.contributor.authorManichaikul, Ani-
dc.contributor.authorMännistö, Satu-
dc.contributor.authorMarques-Vidal, Pedro-
dc.contributor.authorMonda, Keri L.-
dc.contributor.authorNgwa, Julius S.-
dc.contributor.authorPerusse, Louis-
dc.contributor.authorvan Rooij, Frank J.A.-
dc.contributor.authorXiang, Yong Bing-
dc.contributor.authorWen, Wanqing-
dc.contributor.authorWojczynski, Mary K.-
dc.contributor.authorZhu, Jingwen-
dc.contributor.authorBorecki, Ingrid B.-
dc.contributor.authorBouchard, Claude-
dc.contributor.authorCai, Qiuyin-
dc.contributor.authorCooper, Cyrus-
dc.contributor.authorDedoussis, George V.-
dc.contributor.authorDeloukas, Panos-
dc.contributor.authorFerrucci, Luigi-
dc.contributor.authorForouhi, Nita G.-
dc.contributor.authorHansen, Torben-
dc.contributor.authorChristiansen, Lene-
dc.contributor.authorHofman, Albert-
dc.contributor.authorJohansson, Ingegerd-
dc.contributor.authorJørgensen, Torben-
dc.contributor.authorKarasawa, Shigeru-
dc.contributor.authorKhaw, Kay Tee-
dc.contributor.authorKim, Mi Kyung-
dc.contributor.authorKristiansson, Kati-
dc.contributor.authorLi, Huaixing-
dc.contributor.authorLin, Xu-
dc.contributor.authorLiu, Yongmei-
dc.contributor.authorLohman, Kurt K.-
dc.contributor.authorLong, Jirong-
dc.contributor.authorMikkilä, Vera-
dc.contributor.authorMozaffarian, Dariush-
dc.contributor.authorNorth, Kari-
dc.contributor.authorPedersen, Oluf-
dc.contributor.authorRaitakari, Olli-
dc.contributor.authorRissanen, Harri-
dc.contributor.authorTuomilehto, Jaakko-
dc.contributor.authorvan der Schouw, Yvonne T.-
dc.contributor.authorUitterlinden, André G.-
dc.contributor.authorZillikens, M. Carola-
dc.contributor.authorFranco, Oscar H.-
dc.contributor.authorShyong Tai, E.-
dc.contributor.authorOu Shu, Xiao-
dc.contributor.authorSiscovick, David S.-
dc.contributor.authorToft, Ulla-
dc.contributor.authorVerschuren, W. M.Monique-
dc.contributor.authorVollenweider, Peter-
dc.contributor.authorWareham, Nicholas J.-
dc.contributor.authorWitteman, Jacqueline C.M.-
dc.contributor.authorZheng, Wei-
dc.contributor.authorRidker, Paul M.-
dc.contributor.authorKang, Jae H.-
dc.contributor.authorLiang, Liming-
dc.contributor.authorJensen, Majken K.-
dc.contributor.authorCurhan, Gary C.-
dc.contributor.authorPasquale, Louis R.-
dc.contributor.authorHunter, David J.-
dc.contributor.authorMohlke, Karen L.-
dc.contributor.authorUusitupa, Matti-
dc.contributor.authorCupples, L. Adrienne-
dc.contributor.authorRankinen, Tuomo-
dc.date.accessioned2018-09-12T02:00:45Z-
dc.date.available2018-09-12T02:00:45Z-
dc.date.issued2014-
dc.identifier.citationHuman molecular genetics, 2014, v. 23, n. 25, p. 6961-6972-
dc.identifier.urihttp://hdl.handle.net/10722/260210-
dc.description.abstract© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177,330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.-
dc.languageeng-
dc.relation.ispartofHuman molecular genetics-
dc.titleFTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1093/hmg/ddu411-
dc.identifier.pmid25104851-
dc.identifier.scopuseid_2-s2.0-84914107948-
dc.identifier.volume23-
dc.identifier.issue25-
dc.identifier.spage6961-
dc.identifier.epage6972-
dc.identifier.eissn1460-2083-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats