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Conference Paper: Changing Paradigm in the Surgical Management of Hepatocellular Carcinoma With Salvage Transplantation

TitleChanging Paradigm in the Surgical Management of Hepatocellular Carcinoma With Salvage Transplantation
Authors
Issue Date2018
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/transproceed
Citation
Asian Transplantation Week 2017, Incheon, Korea, 18-22 October 2017. In Transplantation Proceedings, v. 50 n. 4, p. 1087-1093 How to Cite?
AbstractObjective: The objective of this study was to compare the long-term outcomes of primary and salvage liver transplantation for patients with hepatocellular carcinoma (HCC). Method: This was a 10-year retrospective analysis in a tertiary referral center. Results: There were 184 patients recruited (primary liver transplantation [pLT]:salvage liver transplantation [sLT], 143:41). The median follow-up time was 79 months. Operation time was shorter in the pLT group than the sLT group (661 ± 164 minutes vs 754 ± 206 minutes; P =.01) and the blood loss was 3749 mL and 3545 mL for pLT and sLT, respectively (P =.735). The reoperation rate was 5.6% and 4.9%, respectively (P = 1.0). The 5-year overall and disease-free survival rates from the time of transplantation for pLT and sLT were 84.1% versus 70.2% (P =.01) and 82.2% versus 65.8% (P =.01), respectively. The 5-year overall survival rate from the time of primary treatment for sLT was 80.3% (P =.1). Subgroup analysis of sLT showed that young age (50 vs 56 year old; P =.004) was the only factor associated with poor overall survival. Young age (P =.004) and microvascular permeation (P =.008) in the recurrent tumor were associated with HCC recurrence. Young age stands out to be the only independent factor associated with HCC recurrence. Conclusion: sLT is the treatment of choice for patients with recurrent HCC in regions of graft shortage.
Persistent Identifierhttp://hdl.handle.net/10722/259376
ISSN
2017 Impact Factor: 0.806
2015 SCImago Journal Rankings: 0.455
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, KW-
dc.contributor.authorChan, ACY-
dc.contributor.authorShe, WH-
dc.contributor.authorChok, KSH-
dc.contributor.authorCheung, TT-
dc.contributor.authorDai, WC-
dc.contributor.authorFung, JYY-
dc.contributor.authorLo, CM-
dc.date.accessioned2018-09-03T04:06:22Z-
dc.date.available2018-09-03T04:06:22Z-
dc.date.issued2018-
dc.identifier.citationAsian Transplantation Week 2017, Incheon, Korea, 18-22 October 2017. In Transplantation Proceedings, v. 50 n. 4, p. 1087-1093-
dc.identifier.issn0041-1345-
dc.identifier.urihttp://hdl.handle.net/10722/259376-
dc.description.abstractObjective: The objective of this study was to compare the long-term outcomes of primary and salvage liver transplantation for patients with hepatocellular carcinoma (HCC). Method: This was a 10-year retrospective analysis in a tertiary referral center. Results: There were 184 patients recruited (primary liver transplantation [pLT]:salvage liver transplantation [sLT], 143:41). The median follow-up time was 79 months. Operation time was shorter in the pLT group than the sLT group (661 ± 164 minutes vs 754 ± 206 minutes; P =.01) and the blood loss was 3749 mL and 3545 mL for pLT and sLT, respectively (P =.735). The reoperation rate was 5.6% and 4.9%, respectively (P = 1.0). The 5-year overall and disease-free survival rates from the time of transplantation for pLT and sLT were 84.1% versus 70.2% (P =.01) and 82.2% versus 65.8% (P =.01), respectively. The 5-year overall survival rate from the time of primary treatment for sLT was 80.3% (P =.1). Subgroup analysis of sLT showed that young age (50 vs 56 year old; P =.004) was the only factor associated with poor overall survival. Young age (P =.004) and microvascular permeation (P =.008) in the recurrent tumor were associated with HCC recurrence. Young age stands out to be the only independent factor associated with HCC recurrence. Conclusion: sLT is the treatment of choice for patients with recurrent HCC in regions of graft shortage.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/transproceed-
dc.relation.ispartofTransplantation Proceedings-
dc.titleChanging Paradigm in the Surgical Management of Hepatocellular Carcinoma With Salvage Transplantation-
dc.typeConference_Paper-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailShe, WH: brianshe@hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailDai, WC: daiwc@HKUCC-COM.hku.hk-
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.transproceed.2018.01.025-
dc.identifier.scopuseid_2-s2.0-85046693736-
dc.identifier.hkuros288587-
dc.identifier.volume50-
dc.identifier.issue4-
dc.identifier.spage1087-
dc.identifier.epage1093-
dc.identifier.isiWOS:000431940700026-
dc.publisher.placeUnited States-

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