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Article: Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis

TitleNon-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis
Authors
KeywordsChronic allograft nephropathy
Kidney
Shear wave elastography
Transplantation
Ultrasound
Issue Date2018
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU
Citation
International Journal of Urology, 2018, v. 25 n. 5, p. 450-455 How to Cite?
AbstractObjectives: To evaluate the use of shear wave elastography in assessment of kidney allograft tubulointerstitial fibrosis. Methods: Shear wave elastography assessment was carried out by two independent operators in kidney transplant recipients who underwent allograft biopsy for clinical indications (i.e. rising creatinine >15% or proteinuria >1 g/day). Allograft biopsies were interpreted by the same pathologist according to the 2013 Banff Classification. Results: A total of 40 elastography scans were carried out (median creatinine 172.5 μmol/L [interquartile range 133.8–281.8 μmol/L]). Median tissue stiffness at the cortex (22.6 kPa [interquartile range 18.8–25.7 kPa] vs 22.3 kPa [interquartile range 19.0–26.5 kPa], P = 0.70) and medulla (15.0 kPa [interquartile range 13.7–18.0 kPa] vs 15.6 kPa [interquartile range 14.4–18.2 kPa]) showed no significant differences between the two observers. Interobserver agreement was satisfactory (intraclass correlation coefficient of the cortex 0.84, 95% CI 0.70–0.92 and intraclass correlation coefficient of the medulla 0.88, 95% CI 0.78–0.94). The areas under the receiver operating characteristic curves for detection of tubulointerstitial fibrosis were estimated to be 0.75 (95% CI 0.61–0.89), 0.85 (95% CI 0.75–0.95) and 0.65 (95% CI 0.53–0.78) for cortical, medullary tissue stiffness and serum creatinine, respectively. Conclusions: Shear wave elastography can be used as a non-invasive tool to evaluate kidney allograft fibrosis with reasonable interobserver agreement and superior test performance to serum creatinine in detecting early tubulointerstitial fibrosis.
Persistent Identifierhttp://hdl.handle.net/10722/259362
ISSN
2017 Impact Factor: 1.941
2015 SCImago Journal Rankings: 0.841
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, MK-
dc.contributor.authorLaw, HK-
dc.contributor.authorTse, KS-
dc.contributor.authorChan, KW-
dc.contributor.authorChan, GC-
dc.contributor.authorYap, YHD-
dc.contributor.authorMok, MM-
dc.contributor.authorKwan, LP-
dc.contributor.authorTang, SCW-
dc.contributor.authorChoy, BY-
dc.contributor.authorChan, DTM-
dc.date.accessioned2018-09-03T04:06:08Z-
dc.date.available2018-09-03T04:06:08Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Urology, 2018, v. 25 n. 5, p. 450-455-
dc.identifier.issn0919-8172-
dc.identifier.urihttp://hdl.handle.net/10722/259362-
dc.description.abstractObjectives: To evaluate the use of shear wave elastography in assessment of kidney allograft tubulointerstitial fibrosis. Methods: Shear wave elastography assessment was carried out by two independent operators in kidney transplant recipients who underwent allograft biopsy for clinical indications (i.e. rising creatinine >15% or proteinuria >1 g/day). Allograft biopsies were interpreted by the same pathologist according to the 2013 Banff Classification. Results: A total of 40 elastography scans were carried out (median creatinine 172.5 μmol/L [interquartile range 133.8–281.8 μmol/L]). Median tissue stiffness at the cortex (22.6 kPa [interquartile range 18.8–25.7 kPa] vs 22.3 kPa [interquartile range 19.0–26.5 kPa], P = 0.70) and medulla (15.0 kPa [interquartile range 13.7–18.0 kPa] vs 15.6 kPa [interquartile range 14.4–18.2 kPa]) showed no significant differences between the two observers. Interobserver agreement was satisfactory (intraclass correlation coefficient of the cortex 0.84, 95% CI 0.70–0.92 and intraclass correlation coefficient of the medulla 0.88, 95% CI 0.78–0.94). The areas under the receiver operating characteristic curves for detection of tubulointerstitial fibrosis were estimated to be 0.75 (95% CI 0.61–0.89), 0.85 (95% CI 0.75–0.95) and 0.65 (95% CI 0.53–0.78) for cortical, medullary tissue stiffness and serum creatinine, respectively. Conclusions: Shear wave elastography can be used as a non-invasive tool to evaluate kidney allograft fibrosis with reasonable interobserver agreement and superior test performance to serum creatinine in detecting early tubulointerstitial fibrosis.-
dc.languageeng-
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU-
dc.relation.ispartofInternational Journal of Urology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectChronic allograft nephropathy-
dc.subjectKidney-
dc.subjectShear wave elastography-
dc.subjectTransplantation-
dc.subjectUltrasound-
dc.titleNon-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis-
dc.typeArticle-
dc.identifier.emailChan, KW: chriskwc@hku.hk-
dc.identifier.emailYap, YHD: desmondy@hku.hk-
dc.identifier.emailTang, SCW: scwtang@hku.hk-
dc.identifier.emailChan, DTM: dtmchan@hkucc.hku.hk-
dc.identifier.authorityYap, YHD=rp01607-
dc.identifier.authorityTang, SCW=rp00480-
dc.identifier.authorityChan, DTM=rp00394-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/iju.13536-
dc.identifier.scopuseid_2-s2.0-85042046855-
dc.identifier.hkuros288075-
dc.identifier.volume25-
dc.identifier.issue5-
dc.identifier.spage450-
dc.identifier.epage455-
dc.identifier.isiWOS:000431652000010-
dc.publisher.placeAustralia-

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