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Article: Microvascular Submandibular Gland Transplantation for Severe Keratoconjunctivitis Sicca: A Single-Institution Experience of 61 Grafts

TitleMicrovascular Submandibular Gland Transplantation for Severe Keratoconjunctivitis Sicca: A Single-Institution Experience of 61 Grafts
Authors
Issue Date2018
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom
Citation
British Journal of Oral and Maxillofacial Surgery, 2018, p. S0278-2391(18)30431-2 How to Cite?
AbstractPURPOSE: Keratoconjunctivitis sicca (KCS) is a relatively common disease that results in discomfort, tear film instability, visual impairment, and ocular surface damage. Artificial tear substitutes may be suitable for the treatment of mild KCS, but no effective treatment currently exists for severe KCS. Therefore, this study evaluated the effectiveness of autologous microvascular submandibular gland transplantation in the treatment of severe KCS. PATIENTS AND METHODS: A total of 61 eyes (56 patients) with severe KCS were treated with autologous submandibular gland transplantation from June 2002 to June 2017. The cephalic vein or the great saphenous vein was applied to solve the problem of unmatched veins. RESULTS: In 53 cases (53 of 56, 94.6%), 58 glands (58 of 61, 95.1%) were transplanted successfully. The mean Schirmer I test value improved from 0.78 ± 0.84 mm preoperatively to 18.83 ± 5.72 mm in the stable period after transplantation. Epiphora (14 of 58, 24.14%) was the most common complication of this procedure. Other postoperative complications included venous thrombosis (6 of 61, 9.84%), local infection (2 of 58, 3.45%), xerostomia (2 of 53, 3.77%), duct fistula (1 of 58, 1.72%), sialolithiasis (1 of 58, 1.72%), and ranula (1 of 58, 1.72%). CONCLUSIONS: Autologous microvascular submandibular gland transplantation is a credible and effective solution for severe KCS.
Persistent Identifierhttp://hdl.handle.net/10722/259159
ISSN
2017 Impact Factor: 1.26
2015 SCImago Journal Rankings: 0.887
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, DK-
dc.contributor.authorZhang, SE-
dc.contributor.authorSu, Y-
dc.contributor.authorZheng, GS-
dc.contributor.authorYang, WF-
dc.contributor.authorLiao, GQ-
dc.date.accessioned2018-09-03T04:02:29Z-
dc.date.available2018-09-03T04:02:29Z-
dc.date.issued2018-
dc.identifier.citationBritish Journal of Oral and Maxillofacial Surgery, 2018, p. S0278-2391(18)30431-2-
dc.identifier.issn0266-4356-
dc.identifier.urihttp://hdl.handle.net/10722/259159-
dc.description.abstractPURPOSE: Keratoconjunctivitis sicca (KCS) is a relatively common disease that results in discomfort, tear film instability, visual impairment, and ocular surface damage. Artificial tear substitutes may be suitable for the treatment of mild KCS, but no effective treatment currently exists for severe KCS. Therefore, this study evaluated the effectiveness of autologous microvascular submandibular gland transplantation in the treatment of severe KCS. PATIENTS AND METHODS: A total of 61 eyes (56 patients) with severe KCS were treated with autologous submandibular gland transplantation from June 2002 to June 2017. The cephalic vein or the great saphenous vein was applied to solve the problem of unmatched veins. RESULTS: In 53 cases (53 of 56, 94.6%), 58 glands (58 of 61, 95.1%) were transplanted successfully. The mean Schirmer I test value improved from 0.78 ± 0.84 mm preoperatively to 18.83 ± 5.72 mm in the stable period after transplantation. Epiphora (14 of 58, 24.14%) was the most common complication of this procedure. Other postoperative complications included venous thrombosis (6 of 61, 9.84%), local infection (2 of 58, 3.45%), xerostomia (2 of 53, 3.77%), duct fistula (1 of 58, 1.72%), sialolithiasis (1 of 58, 1.72%), and ranula (1 of 58, 1.72%). CONCLUSIONS: Autologous microvascular submandibular gland transplantation is a credible and effective solution for severe KCS.-
dc.languageeng-
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom-
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgery-
dc.titleMicrovascular Submandibular Gland Transplantation for Severe Keratoconjunctivitis Sicca: A Single-Institution Experience of 61 Grafts-
dc.typeArticle-
dc.identifier.emailSu, Y: richsu@hku.hk-
dc.identifier.authoritySu, Y=rp01916-
dc.identifier.doi10.1016/j.joms.2018.05.008-
dc.identifier.pmid29864431-
dc.identifier.hkuros289760-
dc.identifier.volume2018 Jun 2-
dc.identifier.spageS0278-
dc.identifier.epage2391(18)30431-
dc.identifier.isiWOS:000448283300037-
dc.publisher.placeUnited Kingdom-

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