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Article: Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population

TitleMitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population
Authors
KeywordsAssociation analysis
case-control study
head and neck
mitochondrial DNA copy number
squamous cell carcinoma
Issue Date2018
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2045-7634
Citation
Cancer Medicine, 2018, v. 7 n. 6, p. 2776-2782 How to Cite?
AbstractMitochondria show the special role in cellular bioenergy and many essential physiological activities. Previous researches have suggested that variations of mitochondrial DNA copy number contribute to development of different types of carcinomas. However, the relationship of mtDNA copy number in peripheral blood leukocytes (PBLs) with the risk of head and neck squamous cell carcinoma (HNSCC) is still inconclusive. We investigated the association of mtDNA with HNSCC risk through a case-control study including 570 HNSCC cases and 597 cancer-free controls. mtDNA copy number in PBLs was measured by real-time qPCR. Logistic regression was performed to estimate the association between the mtDNA copy number in PBLs and HNSCC risk. A U-shaped relation between the mtDNA copy number and HNSCC risk was found. Compared with those in the second quartile group, the adjusted odds ratios (ORs) and 95% confidence interval (CI) for those in the first and the forth quartile groups were 1.95 (1.37-2.76) and 2.16 (1.53-3.04), respectively. Using restricted cubic spline analysis, we confirmed such a significant U-shaped relation. Furthermore, the U-shaped association remained significant in different subgroups stratified by age, gender, tobacco smoking, and alcohol consumption. Both extremely low and high mtDNA copy numbers had significant associations with the increased HNSCC risk.
Persistent Identifierhttp://hdl.handle.net/10722/259156
ISSN
2017 Impact Factor: 3.202
2015 SCImago Journal Rankings: 1.811
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, L-
dc.contributor.authorLv, H-
dc.contributor.authorJi, P-
dc.contributor.authorZhu, X-
dc.contributor.authorYuan, H-
dc.contributor.authorJin, G-
dc.contributor.authorDai, J-
dc.contributor.authorHu, Z-
dc.contributor.authorSu, Y-
dc.contributor.authorMa, H-
dc.date.accessioned2018-09-03T04:02:26Z-
dc.date.available2018-09-03T04:02:26Z-
dc.date.issued2018-
dc.identifier.citationCancer Medicine, 2018, v. 7 n. 6, p. 2776-2782-
dc.identifier.issn2045-7634-
dc.identifier.urihttp://hdl.handle.net/10722/259156-
dc.description.abstractMitochondria show the special role in cellular bioenergy and many essential physiological activities. Previous researches have suggested that variations of mitochondrial DNA copy number contribute to development of different types of carcinomas. However, the relationship of mtDNA copy number in peripheral blood leukocytes (PBLs) with the risk of head and neck squamous cell carcinoma (HNSCC) is still inconclusive. We investigated the association of mtDNA with HNSCC risk through a case-control study including 570 HNSCC cases and 597 cancer-free controls. mtDNA copy number in PBLs was measured by real-time qPCR. Logistic regression was performed to estimate the association between the mtDNA copy number in PBLs and HNSCC risk. A U-shaped relation between the mtDNA copy number and HNSCC risk was found. Compared with those in the second quartile group, the adjusted odds ratios (ORs) and 95% confidence interval (CI) for those in the first and the forth quartile groups were 1.95 (1.37-2.76) and 2.16 (1.53-3.04), respectively. Using restricted cubic spline analysis, we confirmed such a significant U-shaped relation. Furthermore, the U-shaped association remained significant in different subgroups stratified by age, gender, tobacco smoking, and alcohol consumption. Both extremely low and high mtDNA copy numbers had significant associations with the increased HNSCC risk.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2045-7634-
dc.relation.ispartofCancer Medicine-
dc.rightsCancer Medicine. Copyright © John Wiley & Sons Ltd.-
dc.rightsPreprint: This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Postprint: This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Special Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAssociation analysis-
dc.subjectcase-control study-
dc.subjecthead and neck-
dc.subjectmitochondrial DNA copy number-
dc.subjectsquamous cell carcinoma-
dc.titleMitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population-
dc.typeArticle-
dc.identifier.emailSu, Y: richsu@hku.hk-
dc.identifier.authoritySu, Y=rp01916-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/cam4.1452-
dc.identifier.pmid29673117-
dc.identifier.pmcidPMC6010846-
dc.identifier.hkuros289740-
dc.identifier.volume7-
dc.identifier.issue6-
dc.identifier.spage2776-
dc.identifier.epage2782-
dc.identifier.isiWOS:000435771000051-
dc.publisher.placeUnited Kingdom-

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