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Article: Effect of combined treatment with MLC601 (NeuroAiDTM) and rehabilitation on post-stroke recovery: the CHIMES and CHIMES-E studies

TitleEffect of combined treatment with MLC601 (NeuroAiDTM) and rehabilitation on post-stroke recovery: the CHIMES and CHIMES-E studies
Authors
KeywordsAcute stroke
Stroke recovery
MLC601
NeuroAiD
Rehabilitation
Combination
Clinical trial
Long-term outcome
Issue Date2018
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CED
Citation
Cerebrovascular Diseases, 2018, v. 46 n. 1-2, p. 82-88 How to Cite?
AbstractBackground and Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. CHIMES-E was a 24-month follow-up study of subjects included in CHIMES, a multi-centre, double-blind placebo-controlled trial which randomized subjects with acute ischemic stroke, to either MLC601 or placebo for 3 months in addition to standard stroke treatment and rehabilitation. Subjects were stratified according to whether they received or did not receive persistent rehabilitation up to month (M)3 (non- randomized allocation) and by treatment group. The modified Rankin Scale (mRS) and Barthel Index were assessed at month (M) 3, M6, M12, M18, and M24. Results: Of 880 subjects in CHIMES-E, data on rehabilitation at M3 were available in 807 (91.7%, mean age 61.8 ± 11.3 years, 36% female). After adjusting for prognostic factors of poor outcome (age, sex, pre-stroke mRS, baseline National Institute of Health Stroke Scale, and stroke onset-to-study-treatment time), subjects who received persistent rehabilitation showed consistently higher treatment effect in favor of MLC601 for all time points on mRS 0–1 dichotomy analysis (ORs 1.85 at M3, 2.18 at M6, 2.42 at M12, 1.94 at M18, 1.87 at M24), mRS ordinal analysis (ORs 1.37 at M3, 1.40 at M6, 1.53 at M12, 1.50 at M18, 1.38 at M24), and BI ≥95 dichotomy analysis (ORs 1.39 at M3, 1.95 at M6, 1.56 at M12, 1.56 at M18, 1.46 at M24) compared to those who did not receive persistent rehabilitation. Conclusions: More subjects on MLC601 improved to functional independence compared to placebo among subjects receiving persistent rehabilitation up to M3. The larger treatment effect of MLC601 was sustained over 2 years which supports the hypothesis that MLC601 combined with rehabilitation might have beneficial and sustained effects on neuro-repair processes after stroke. There is a need for more data on the effect of combining rehabilitation programs with stroke recovery treatments.
Persistent Identifierhttp://hdl.handle.net/10722/258952
ISSN
2017 Impact Factor: 2.931
2015 SCImago Journal Rankings: 1.744
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSuwanwela, NC-
dc.contributor.authorChen, CLH-
dc.contributor.authorLee, CF-
dc.contributor.authorYoung, SH-
dc.contributor.authorTay, SS-
dc.contributor.authorUmapathi, T-
dc.contributor.authorLao, AY-
dc.contributor.authorGan, HH-
dc.contributor.authorNavarro, JC-
dc.contributor.authorChang, HM-
dc.contributor.authorAdvincula, JM-
dc.contributor.authorMuengtaweepongsa, S-
dc.contributor.authorChan, BPL-
dc.contributor.authorChua, CL-
dc.contributor.authorWijekoon, N-
dc.contributor.authorde Silva, HA-
dc.contributor.authorHiyadan, JHB-
dc.contributor.authorWong, KSL-
dc.contributor.authorPoungvarin, N-
dc.contributor.authorEow, GB-
dc.contributor.authorVenketasubramanian, N-
dc.date.accessioned2018-09-03T03:58:59Z-
dc.date.available2018-09-03T03:58:59Z-
dc.date.issued2018-
dc.identifier.citationCerebrovascular Diseases, 2018, v. 46 n. 1-2, p. 82-88-
dc.identifier.issn1015-9770-
dc.identifier.urihttp://hdl.handle.net/10722/258952-
dc.description.abstractBackground and Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. CHIMES-E was a 24-month follow-up study of subjects included in CHIMES, a multi-centre, double-blind placebo-controlled trial which randomized subjects with acute ischemic stroke, to either MLC601 or placebo for 3 months in addition to standard stroke treatment and rehabilitation. Subjects were stratified according to whether they received or did not receive persistent rehabilitation up to month (M)3 (non- randomized allocation) and by treatment group. The modified Rankin Scale (mRS) and Barthel Index were assessed at month (M) 3, M6, M12, M18, and M24. Results: Of 880 subjects in CHIMES-E, data on rehabilitation at M3 were available in 807 (91.7%, mean age 61.8 ± 11.3 years, 36% female). After adjusting for prognostic factors of poor outcome (age, sex, pre-stroke mRS, baseline National Institute of Health Stroke Scale, and stroke onset-to-study-treatment time), subjects who received persistent rehabilitation showed consistently higher treatment effect in favor of MLC601 for all time points on mRS 0–1 dichotomy analysis (ORs 1.85 at M3, 2.18 at M6, 2.42 at M12, 1.94 at M18, 1.87 at M24), mRS ordinal analysis (ORs 1.37 at M3, 1.40 at M6, 1.53 at M12, 1.50 at M18, 1.38 at M24), and BI ≥95 dichotomy analysis (ORs 1.39 at M3, 1.95 at M6, 1.56 at M12, 1.56 at M18, 1.46 at M24) compared to those who did not receive persistent rehabilitation. Conclusions: More subjects on MLC601 improved to functional independence compared to placebo among subjects receiving persistent rehabilitation up to M3. The larger treatment effect of MLC601 was sustained over 2 years which supports the hypothesis that MLC601 combined with rehabilitation might have beneficial and sustained effects on neuro-repair processes after stroke. There is a need for more data on the effect of combining rehabilitation programs with stroke recovery treatments.-
dc.languageeng-
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CED-
dc.relation.ispartofCerebrovascular Diseases-
dc.rightsCerebrovascular Diseases. Copyright © S Karger AG.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAcute stroke-
dc.subjectStroke recovery-
dc.subjectMLC601-
dc.subjectNeuroAiD-
dc.subjectRehabilitation-
dc.subjectCombination-
dc.subjectClinical trial-
dc.subjectLong-term outcome-
dc.titleEffect of combined treatment with MLC601 (NeuroAiDTM) and rehabilitation on post-stroke recovery: the CHIMES and CHIMES-E studies-
dc.typeArticle-
dc.identifier.emailLee, CF: fanlee@hku.hk-
dc.identifier.authorityLee, CF=rp02103-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1159/000492625-
dc.identifier.pmid30184553-
dc.identifier.pmcidPMC6214602-
dc.identifier.scopuseid_2-s2.0-85053123237-
dc.identifier.hkuros287973-
dc.identifier.volume46-
dc.identifier.issue1-2-
dc.identifier.spage82-
dc.identifier.epage88-
dc.identifier.isiWOS:000445951600012-
dc.publisher.placeSwitzerland-

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