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Article: Protection by universal influenza vaccine is mediated by memory CD4 T cells

TitleProtection by universal influenza vaccine is mediated by memory CD4 T cells
Authors
Issue Date2018
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2018, v. 36 n. 29, p. 4198-4206 How to Cite?
AbstractThere is a diverse array of influenza viruses which circulate between different species, reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling these viruses. We have developed a novel universal vaccine which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models. Vaccine mediated protection was dependent on influenza-specific CD4+ T cells, whereby depletion of CD4+ T cells at either vaccination or challenge time points significantly reduced survival in mice. Vaccine memory CD4+ T cells were needed for early antibody production and CD8+ T cell recall responses. Furthermore, influenza-specific CD4+ T cells from vaccination manifested primarily Tfh and Th1 profiles with anti-viral cytokine production. The vaccine boosted H5-specific T cells from human PBMCs, specifically CD4+ and CD8+ T effector memory type, ensuring the vaccine was truly universal for its future application. These findings have implications for the development and optimization of T cell activating vaccines for universal immunity against influenza.
Persistent Identifierhttp://hdl.handle.net/10722/258394
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044

 

DC FieldValueLanguage
dc.contributor.authorDoak, SA-
dc.contributor.authorLi, TW-
dc.contributor.authorLi, PYA-
dc.contributor.authorBULL, MB-
dc.contributor.authorWaldmann, TA-
dc.contributor.authorPerera, LP-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorPoon, LML-
dc.date.accessioned2018-08-22T01:37:46Z-
dc.date.available2018-08-22T01:37:46Z-
dc.date.issued2018-
dc.identifier.citationVaccine, 2018, v. 36 n. 29, p. 4198-4206-
dc.identifier.issn0264-410X-
dc.identifier.urihttp://hdl.handle.net/10722/258394-
dc.description.abstractThere is a diverse array of influenza viruses which circulate between different species, reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling these viruses. We have developed a novel universal vaccine which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models. Vaccine mediated protection was dependent on influenza-specific CD4+ T cells, whereby depletion of CD4+ T cells at either vaccination or challenge time points significantly reduced survival in mice. Vaccine memory CD4+ T cells were needed for early antibody production and CD8+ T cell recall responses. Furthermore, influenza-specific CD4+ T cells from vaccination manifested primarily Tfh and Th1 profiles with anti-viral cytokine production. The vaccine boosted H5-specific T cells from human PBMCs, specifically CD4+ and CD8+ T effector memory type, ensuring the vaccine was truly universal for its future application. These findings have implications for the development and optimization of T cell activating vaccines for universal immunity against influenza.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine-
dc.relation.ispartofVaccine-
dc.titleProtection by universal influenza vaccine is mediated by memory CD4 T cells-
dc.typeArticle-
dc.identifier.emailDoak, SA: sophiev@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.authorityDoak, SA=rp02141-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityPoon, LML=rp00484-
dc.identifier.doi10.1016/j.vaccine.2018.06.007-
dc.identifier.hkuros286582-
dc.identifier.volume36-
dc.identifier.issue29-
dc.identifier.spage4198-
dc.identifier.epage4206-
dc.publisher.placeUnited Kingdom-

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