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Article: Leukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese

TitleLeukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese
Authors
KeywordsNPC risk
Prognostic marker
Leucocyte telomere length
Survival
Telomere biology
Issue Date2018
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal of Cancer, 2018, v. 143 n. 9, p. 2289-2298 How to Cite?
AbstractTelomere shortening occurs as an early event in tumorigenesis. The TERT‐CLPTM1L locus associates with nasopharyngeal carcinoma (NPC) risk. It remains unknown if leukocyte telomere length (LTL) associates with NPC risk and survival. The relative LTL (rLTL) was measured by quantitative‐PCR in 2,996 individuals comprised of 1,284 NPC cases and 1712 matched controls. The odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression. The hazard ratio (HR) and 95% CI were calculated by Cox regression for survival analysis with rLTL and other clinical parameters in 1,243 NPC with a minimum follow‐up period of 25 months. NPC patients had significantly shorter telomere length than controls. Shorter rLTL significantly associated with increased NPC risk, when the individuals were dichotomized into long and short telomeres based on median‐split rLTL in the control group (OR = 2.317; 95% CI = 1.989–2.700, p = 4.10 × 10−27). We observed a significant dose–response association (ptrend = 3.26 × 10−34) between rLTL and NPC risk with OR being 3.555 (95% CI = 2.853–4.429) for the individuals in the first quartile (shortest) compared with normal individuals in the fourth quartile (longest). A multivariate Cox regression analysis adjusted by age demonstrated an independent effect of rLTL on NPC survival for late‐stage NPC patients, when the individuals were categorized into suboptimal rLTL versus the medium rLTL based on a threshold set from normal (HR = 1.471, 95% CI = 1.056–2.048, p = 0.022). Shorter blood telomeres may be markers for higher susceptibility for NPC risk. Suboptimal rLTL may be a poor prognostic factor for advanced NPC patients, as it associates independently with poor survival.
Persistent Identifierhttp://hdl.handle.net/10722/258367
ISSN
2019 Impact Factor: 5.145
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKo, JMY-
dc.contributor.authorTsang, KHK-
dc.contributor.authorDai, W-
dc.contributor.authorChoi, SSA-
dc.contributor.authorLeong, MML-
dc.contributor.authorNgan, KCR-
dc.contributor.authorKwong, DLW-
dc.contributor.authorCheng, A-
dc.contributor.authorLee, AWM-
dc.contributor.authorNg, WT-
dc.contributor.authorTung, S-
dc.contributor.authorLee, VHF-
dc.contributor.authorLam, KO-
dc.contributor.authorChan, CKC-
dc.contributor.authorLung, ML-
dc.date.accessioned2018-08-22T01:37:21Z-
dc.date.available2018-08-22T01:37:21Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Cancer, 2018, v. 143 n. 9, p. 2289-2298-
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/258367-
dc.description.abstractTelomere shortening occurs as an early event in tumorigenesis. The TERT‐CLPTM1L locus associates with nasopharyngeal carcinoma (NPC) risk. It remains unknown if leukocyte telomere length (LTL) associates with NPC risk and survival. The relative LTL (rLTL) was measured by quantitative‐PCR in 2,996 individuals comprised of 1,284 NPC cases and 1712 matched controls. The odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression. The hazard ratio (HR) and 95% CI were calculated by Cox regression for survival analysis with rLTL and other clinical parameters in 1,243 NPC with a minimum follow‐up period of 25 months. NPC patients had significantly shorter telomere length than controls. Shorter rLTL significantly associated with increased NPC risk, when the individuals were dichotomized into long and short telomeres based on median‐split rLTL in the control group (OR = 2.317; 95% CI = 1.989–2.700, p = 4.10 × 10−27). We observed a significant dose–response association (ptrend = 3.26 × 10−34) between rLTL and NPC risk with OR being 3.555 (95% CI = 2.853–4.429) for the individuals in the first quartile (shortest) compared with normal individuals in the fourth quartile (longest). A multivariate Cox regression analysis adjusted by age demonstrated an independent effect of rLTL on NPC survival for late‐stage NPC patients, when the individuals were categorized into suboptimal rLTL versus the medium rLTL based on a threshold set from normal (HR = 1.471, 95% CI = 1.056–2.048, p = 0.022). Shorter blood telomeres may be markers for higher susceptibility for NPC risk. Suboptimal rLTL may be a poor prognostic factor for advanced NPC patients, as it associates independently with poor survival.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home-
dc.relation.ispartofInternational Journal of Cancer-
dc.subjectNPC risk-
dc.subjectPrognostic marker-
dc.subjectLeucocyte telomere length-
dc.subjectSurvival-
dc.subjectTelomere biology-
dc.titleLeukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese-
dc.typeArticle-
dc.identifier.emailKo, JMY: joko@hku.hk-
dc.identifier.emailTsang, KHK: kayt@hku.hk-
dc.identifier.emailDai, W: weidai2@hku.hk-
dc.identifier.emailLeong, MML: merrin@hku.hk-
dc.identifier.emailNgan, KCR: rkcngan@hku.hk-
dc.identifier.emailKwong, DLW: dlwkwong@hku.hk-
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hk-
dc.identifier.emailNg, WT: ngwt1@hkucc.hku.hk-
dc.identifier.emailLee, VHF: vhflee@hku.hk-
dc.identifier.emailLam, KO: lamkaon@hku.hk-
dc.identifier.emailChan, CKC: biocandy@hku.hk-
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.authorityKo, JMY=rp02011-
dc.identifier.authorityDai, W=rp02146-
dc.identifier.authorityNgan, KCR=rp02371-
dc.identifier.authorityKwong, DLW=rp00414-
dc.identifier.authorityLee, AWM=rp02056-
dc.identifier.authorityNg, WT=rp02671-
dc.identifier.authorityLee, VHF=rp00264-
dc.identifier.authorityLam, KO=rp01501-
dc.identifier.authorityLung, ML=rp00300-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ijc.31617-
dc.identifier.pmid29873071-
dc.identifier.scopuseid_2-s2.0-85053183188-
dc.identifier.hkuros286574-
dc.identifier.volume143-
dc.identifier.issue9-
dc.identifier.spage2289-
dc.identifier.epage2298-
dc.identifier.isiWOS:000447767400020-
dc.publisher.placeUnited States-

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