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Article: Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection

TitleReplicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection
Authors
Issue Date2018
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijid
Citation
International Journal of Infectious Diseases, 2018, v. 72, p. 8-10 How to Cite?
AbstractBACKGROUND: Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative. This study examined the duration for detecting MERS-CoV sub-genomic mRNA compared with genomic RNA in diverse respiratory specimens. METHODS: Upper and lower respiratory samples were obtained from 17 MERS-CoV-infected patients. MERS-CoV sub-genomic mRNA was detected by reverse transcription PCR (RT-PCR) and MERS-CoV genomic RNA by real-time RT-PCR. RESULTS: In sputum and transtracheal aspirate, sub-genomic mRNA was detected for up to 4 weeks after symptoms developed, which correlated with the detection of genomic RNA. In oropharyngeal and nasopharyngeal swab specimens, the detection of sub-genomic mRNA and genomic RNA did not correlate. CONCLUSIONS: These findings suggest that MERS-CoV does not replicate well in the upper respiratory tract.
Persistent Identifierhttp://hdl.handle.net/10722/258335
ISSN
2015 Impact Factor: 2.229
2015 SCImago Journal Rankings: 1.148

 

DC FieldValueLanguage
dc.contributor.authorPark, WB-
dc.contributor.authorPoon, LML-
dc.contributor.authorChoi, SJ-
dc.contributor.authorChoe, PG-
dc.contributor.authorSong, KH-
dc.contributor.authorBang, JH-
dc.contributor.authorKim, ES-
dc.contributor.authorKim, HB-
dc.contributor.authorPark, SW-
dc.contributor.authorKim, NJ-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorOh, MD-
dc.date.accessioned2018-08-22T01:36:50Z-
dc.date.available2018-08-22T01:36:50Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Infectious Diseases, 2018, v. 72, p. 8-10-
dc.identifier.issn1201-9712-
dc.identifier.urihttp://hdl.handle.net/10722/258335-
dc.description.abstractBACKGROUND: Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. The detection of MERS-CoV sub-genomic mRNAs indicates that the virus is replicative. This study examined the duration for detecting MERS-CoV sub-genomic mRNA compared with genomic RNA in diverse respiratory specimens. METHODS: Upper and lower respiratory samples were obtained from 17 MERS-CoV-infected patients. MERS-CoV sub-genomic mRNA was detected by reverse transcription PCR (RT-PCR) and MERS-CoV genomic RNA by real-time RT-PCR. RESULTS: In sputum and transtracheal aspirate, sub-genomic mRNA was detected for up to 4 weeks after symptoms developed, which correlated with the detection of genomic RNA. In oropharyngeal and nasopharyngeal swab specimens, the detection of sub-genomic mRNA and genomic RNA did not correlate. CONCLUSIONS: These findings suggest that MERS-CoV does not replicate well in the upper respiratory tract.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijid-
dc.relation.ispartofInternational Journal of Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleReplicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection-
dc.typeArticle-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityPoon, LML=rp00484-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ijid.2018.05.003-
dc.identifier.hkuros286587-
dc.identifier.volume72-
dc.identifier.spage8-
dc.identifier.epage10-
dc.publisher.placeUnited Kingdom-

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