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Article: Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study

TitleExpression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study
Authors
Issue Date2018
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
Citation
Clinical Transplantation, 2018, v. 32 n. 3, p. e13203 How to Cite?
AbstractBACKGROUND: Hepatic progenitor cells (HPC) are induced following liver injury to facilitate regeneration. Acute cellular rejection (ACR) is a common complication after liver transplantation as a result of immune-mediated liver injury. In this study, we characterized HPC phenotype in liver allograft biopsy with ACR. We also explored the correlation between expression HPC immunophenotype and clinicopathological parameters. METHODS: Forty-four liver allograft biopsies performed between 2008 and 2016 in a single center with histologically proven ACR were examined for immunohistochemical expression of HPC markers CK19 and Sox9. The number of positive-staining cells was assessed and correlated with clinicopathological features by statistical analysis. RESULTS: HPC phenotype expression as denoted by CK19 and Sox9 staining was detected in the liver tissue with ACR. The numbers of CK19+ and Sox9+ cells were positively correlated. A larger number of CK19+ cells were associated with higher serum aspartate aminotransferase (AST) level at biopsy. By histological rejection score, a larger number of Sox9+ cells were associated with a higher score of bile duct damage. CONCLUSION: Expression HPC markers were correlated with clinical and histological parameters in ACR. Expression of each individual marker may be more tightly associated with a particular component of the ACR process.
Persistent Identifierhttp://hdl.handle.net/10722/254801
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.821

 

DC FieldValueLanguage
dc.contributor.authorLo, CLR-
dc.contributor.authorChan, KK-
dc.contributor.authorLeung, CO-
dc.contributor.authorNg, IOL-
dc.date.accessioned2018-06-21T01:06:47Z-
dc.date.available2018-06-21T01:06:47Z-
dc.date.issued2018-
dc.identifier.citationClinical Transplantation, 2018, v. 32 n. 3, p. e13203-
dc.identifier.issn0902-0063-
dc.identifier.urihttp://hdl.handle.net/10722/254801-
dc.description.abstractBACKGROUND: Hepatic progenitor cells (HPC) are induced following liver injury to facilitate regeneration. Acute cellular rejection (ACR) is a common complication after liver transplantation as a result of immune-mediated liver injury. In this study, we characterized HPC phenotype in liver allograft biopsy with ACR. We also explored the correlation between expression HPC immunophenotype and clinicopathological parameters. METHODS: Forty-four liver allograft biopsies performed between 2008 and 2016 in a single center with histologically proven ACR were examined for immunohistochemical expression of HPC markers CK19 and Sox9. The number of positive-staining cells was assessed and correlated with clinicopathological features by statistical analysis. RESULTS: HPC phenotype expression as denoted by CK19 and Sox9 staining was detected in the liver tissue with ACR. The numbers of CK19+ and Sox9+ cells were positively correlated. A larger number of CK19+ cells were associated with higher serum aspartate aminotransferase (AST) level at biopsy. By histological rejection score, a larger number of Sox9+ cells were associated with a higher score of bile duct damage. CONCLUSION: Expression HPC markers were correlated with clinical and histological parameters in ACR. Expression of each individual marker may be more tightly associated with a particular component of the ACR process.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR-
dc.relation.ispartofClinical Transplantation-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article].-
dc.titleExpression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study-
dc.typeArticle-
dc.identifier.emailLo, CLR: loregina@hku.hk-
dc.identifier.emailChan, KK: kuiasdf@hkucc.hk-
dc.identifier.emailNg, IOL: iolng@hku.hk-
dc.identifier.authorityLo, CLR=rp01359-
dc.identifier.authorityNg, IOL=rp00335-
dc.identifier.doi10.1111/ctr.13203-
dc.identifier.pmid29345755-
dc.identifier.hkuros285480-
dc.identifier.hkuros286502-
dc.identifier.volume32-
dc.identifier.issue3-
dc.identifier.spagee13203-
dc.identifier.epagee13203-
dc.publisher.placeDenmark-

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