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Article: Placental site trophoblastic tumor: A distinct entity of gestational trophoblastic disease: Experience from a tertiary referral center in Hong Kong
Title | Placental site trophoblastic tumor: A distinct entity of gestational trophoblastic disease: Experience from a tertiary referral center in Hong Kong |
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Authors | |
Keywords | Chemotherapy Uterine neoplasms Trophoblastic tumor Prognosis Placental-site tro phoblastic tumor Placental site Hysterectomy Gestational trophoblastic neoplasia Gestational trophoblastic disease Choriocarcinoma |
Issue Date | 2016 |
Citation | Journal of Reproductive Medicine, 2016, v. 61, n. 4, p. 351-356 How to Cite? |
Abstract | © Journal of Reproductive Medicine®, Inc. OBJECTIVE: To review the clinical and pathological characteristics of patients with placental site trophoblastic tumor (PSTT) managed in a tertiary referral center in Hong Kong. STUDY DESIGN: Patients with a diagnosis of PSTT from 1995 to 2012 were identified from a computer database. Clinical and pathological data were obtained from medical records and the electronic database. RESULTS: Ten patients with PSTT were identified. Only 4 patients (40%) had disease confined to the uterus at presentation (Stage I). The most common site of metastasis was the lung. Four patients had pretreatment serum hCG levels < 1,000 IU/L, and all of them had disease confined to the uterus. Of the 4 patients with Stage I disease 3 had hysterectomy only and 1 had both hysterectomy and chemotherapy. All 4 patients achieved complete remission, although 1 of them had a recurrence successfully treated with chemotherapy. For patients with Stage III/IV disease most of them had both hysterectomy and chemotherapy. Only 1 patient (20%) was alive without evidence of disease. CONCLUSION: Patients with Stage I disease have excellent prognosis after hysterectomy, and adjuvant treatment is not recommended. A low pretreatment serum hCG level ( < 1,000 IU/L) was a good predictor of early stage disease. The prognosis for patients with metastatic disease was poor despite surgery and com bination chemotherapy. |
Persistent Identifier | http://hdl.handle.net/10722/254563 |
ISSN | 2021 Impact Factor: 0.218 2020 SCImago Journal Rankings: 0.132 |
DC Field | Value | Language |
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dc.contributor.author | Chu, Mandy Man Yee | - |
dc.contributor.author | Tse, Ka Yu | - |
dc.contributor.author | Chan, Karen Kar Loen | - |
dc.contributor.author | Cheung, Annie Nga Yin | - |
dc.contributor.author | Ngan, Hextan Yuen Sheung | - |
dc.date.accessioned | 2018-06-19T15:40:53Z | - |
dc.date.available | 2018-06-19T15:40:53Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Reproductive Medicine, 2016, v. 61, n. 4, p. 351-356 | - |
dc.identifier.issn | 0024-7758 | - |
dc.identifier.uri | http://hdl.handle.net/10722/254563 | - |
dc.description.abstract | © Journal of Reproductive Medicine®, Inc. OBJECTIVE: To review the clinical and pathological characteristics of patients with placental site trophoblastic tumor (PSTT) managed in a tertiary referral center in Hong Kong. STUDY DESIGN: Patients with a diagnosis of PSTT from 1995 to 2012 were identified from a computer database. Clinical and pathological data were obtained from medical records and the electronic database. RESULTS: Ten patients with PSTT were identified. Only 4 patients (40%) had disease confined to the uterus at presentation (Stage I). The most common site of metastasis was the lung. Four patients had pretreatment serum hCG levels < 1,000 IU/L, and all of them had disease confined to the uterus. Of the 4 patients with Stage I disease 3 had hysterectomy only and 1 had both hysterectomy and chemotherapy. All 4 patients achieved complete remission, although 1 of them had a recurrence successfully treated with chemotherapy. For patients with Stage III/IV disease most of them had both hysterectomy and chemotherapy. Only 1 patient (20%) was alive without evidence of disease. CONCLUSION: Patients with Stage I disease have excellent prognosis after hysterectomy, and adjuvant treatment is not recommended. A low pretreatment serum hCG level ( < 1,000 IU/L) was a good predictor of early stage disease. The prognosis for patients with metastatic disease was poor despite surgery and com bination chemotherapy. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Reproductive Medicine | - |
dc.subject | Chemotherapy | - |
dc.subject | Uterine neoplasms | - |
dc.subject | Trophoblastic tumor | - |
dc.subject | Prognosis | - |
dc.subject | Placental-site tro phoblastic tumor | - |
dc.subject | Placental site | - |
dc.subject | Hysterectomy | - |
dc.subject | Gestational trophoblastic neoplasia | - |
dc.subject | Gestational trophoblastic disease | - |
dc.subject | Choriocarcinoma | - |
dc.title | Placental site trophoblastic tumor: A distinct entity of gestational trophoblastic disease: Experience from a tertiary referral center in Hong Kong | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-84978698457 | - |
dc.identifier.volume | 61 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 351 | - |
dc.identifier.epage | 356 | - |
dc.identifier.issnl | 0024-7758 | - |