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Article: Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

TitleMeta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
Authors
Issue Date2017
Citation
Nature Communications, 2017, v. 8 How to Cite?
Abstract© 2017 The Author(s). Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P < 5 × 10 -8 , METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
Persistent Identifierhttp://hdl.handle.net/10722/254471

 

DC FieldValueLanguage
dc.contributor.authorHeilmann-Heimbach, Stefanie-
dc.contributor.authorHerold, Christine-
dc.contributor.authorHochfeld, Lara M.-
dc.contributor.authorHillmer, Axel M.-
dc.contributor.authorNyholt, Dale R.-
dc.contributor.authorHecker, Julian-
dc.contributor.authorJaved, Asif-
dc.contributor.authorChew, Elaine G.Y.-
dc.contributor.authorPechlivanis, Sonali-
dc.contributor.authorDrichel, Dmitriy-
dc.contributor.authorHeng, Xiu Ting-
dc.contributor.authorDel Rosario, Ricardo C.H.-
dc.contributor.authorFier, Heide L.-
dc.contributor.authorPaus, Ralf-
dc.contributor.authorRueedi, Rico-
dc.contributor.authorGalesloot, Tessel E.-
dc.contributor.authorMoebus, Susanne-
dc.contributor.authorAnhalt, Thomas-
dc.contributor.authorPrabhakar, Shyam-
dc.contributor.authorLi, Rui-
dc.contributor.authorKanoni, Stavroula-
dc.contributor.authorPapanikolaou, George-
dc.contributor.authorKutalik, Zoltán-
dc.contributor.authorDeloukas, Panos-
dc.contributor.authorPhilpott, Michael P.-
dc.contributor.authorWaeber, Gérard-
dc.contributor.authorSpector, Tim D.-
dc.contributor.authorVollenweider, Peter-
dc.contributor.authorKiemeney, Lambertus A.L.M.-
dc.contributor.authorDedoussis, George-
dc.contributor.authorRichards, J. Brent-
dc.contributor.authorNothnagel, Michael-
dc.contributor.authorMartin, Nicholas G.-
dc.contributor.authorBecker, Tim-
dc.contributor.authorHinds, David A.-
dc.contributor.authorNöthen, Markus M.-
dc.date.accessioned2018-06-19T15:40:39Z-
dc.date.available2018-06-19T15:40:39Z-
dc.date.issued2017-
dc.identifier.citationNature Communications, 2017, v. 8-
dc.identifier.urihttp://hdl.handle.net/10722/254471-
dc.description.abstract© 2017 The Author(s). Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P < 5 × 10 -8 , METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.-
dc.languageeng-
dc.relation.ispartofNature Communications-
dc.titleMeta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ncomms14694-
dc.identifier.scopuseid_2-s2.0-85014867125-
dc.identifier.volume8-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn2041-1723-

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