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- Publisher Website: 10.1016/j.jhep.2005.05.023
- Scopus: eid_2-s2.0-26244435461
- PMID: 16139923
- WOS: WOS:000233003600006
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Article: The impact of maternal HBsAg carrier status on pregnancy outcomes: A case-control study
Title | The impact of maternal HBsAg carrier status on pregnancy outcomes: A case-control study |
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Authors | |
Keywords | Chronic hepatitis B infection Pregnancy outcomes |
Issue Date | 2005 |
Citation | Journal of Hepatology, 2005, v. 43, n. 5, p. 771-775 How to Cite? |
Abstract | Background/Aims: To examine the impact of maternal HBsAg carrier status on pregnancy outcomes. Methods: Two hundred and fifty-three carriers of hepatitis B surface antigen (HBsAg) with singleton pregnancy, were retrospectively compared with 253 controls matched for age and parity and year of delivery. Results: On univariable analysis, HBsAg carriers had higher incidences of threatened preterm labour at < 37 weeks (11.9% vs. 6.3%, P=0.030), preterm birth at < 34 weeks (4.7% vs. 1.2%, P=0.033), gestational diabetes mellitus (19.0% vs. 11.1%, P=0.012) and antepartum haemorrhage (11.5% vs. 5.5%, P=0.026). Their infants had lower Apgar scores at the 1st (8.47±1.67 vs. 8.87±1.07, P=0.001) and 5th minute (9.56±1.29 vs. 9.80±0.54, P=0.007), and increased incidence of intraventricular haemorrhage (4.7% vs. 0.8%, P=0.007). On multivariable analysis, the association between HBsAg carrier state with antepartum haemorrhage, gestational diabetes mellitus and threatened preterm labour were confirmed. Conclusions: HBsAg carriers have increased risk of gestational diabetes mellitus, antepartum haemorrhage, and threatened preterm labour. This may be related to the chronic inflammatory state in these subjects. The role of chronic HBV infection in pregnancy complications has to be further elucidated. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/254423 |
ISSN | 2021 Impact Factor: 30.083 2020 SCImago Journal Rankings: 7.112 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tse, Ka Yu | - |
dc.contributor.author | Lai, Fong Ho | - |
dc.contributor.author | Lao, Terence | - |
dc.date.accessioned | 2018-06-19T15:40:30Z | - |
dc.date.available | 2018-06-19T15:40:30Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Hepatology, 2005, v. 43, n. 5, p. 771-775 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | http://hdl.handle.net/10722/254423 | - |
dc.description.abstract | Background/Aims: To examine the impact of maternal HBsAg carrier status on pregnancy outcomes. Methods: Two hundred and fifty-three carriers of hepatitis B surface antigen (HBsAg) with singleton pregnancy, were retrospectively compared with 253 controls matched for age and parity and year of delivery. Results: On univariable analysis, HBsAg carriers had higher incidences of threatened preterm labour at < 37 weeks (11.9% vs. 6.3%, P=0.030), preterm birth at < 34 weeks (4.7% vs. 1.2%, P=0.033), gestational diabetes mellitus (19.0% vs. 11.1%, P=0.012) and antepartum haemorrhage (11.5% vs. 5.5%, P=0.026). Their infants had lower Apgar scores at the 1st (8.47±1.67 vs. 8.87±1.07, P=0.001) and 5th minute (9.56±1.29 vs. 9.80±0.54, P=0.007), and increased incidence of intraventricular haemorrhage (4.7% vs. 0.8%, P=0.007). On multivariable analysis, the association between HBsAg carrier state with antepartum haemorrhage, gestational diabetes mellitus and threatened preterm labour were confirmed. Conclusions: HBsAg carriers have increased risk of gestational diabetes mellitus, antepartum haemorrhage, and threatened preterm labour. This may be related to the chronic inflammatory state in these subjects. The role of chronic HBV infection in pregnancy complications has to be further elucidated. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Hepatology | - |
dc.subject | Chronic hepatitis B infection | - |
dc.subject | Pregnancy outcomes | - |
dc.title | The impact of maternal HBsAg carrier status on pregnancy outcomes: A case-control study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jhep.2005.05.023 | - |
dc.identifier.pmid | 16139923 | - |
dc.identifier.scopus | eid_2-s2.0-26244435461 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 771 | - |
dc.identifier.epage | 775 | - |
dc.identifier.isi | WOS:000233003600006 | - |
dc.identifier.f1000 | 5041 | - |
dc.identifier.issnl | 0168-8278 | - |