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Article: Breastfeeding And The Risk Of Breast Cancer In Brca1 And Brca2 Mutation Carriers

TitleBreastfeeding And The Risk Of Breast Cancer In Brca1 And Brca2 Mutation Carriers
Authors
Issue Date2012
PublisherBioMed Central Ltd. The Journal's web site is located at http://breast-cancer-research.com/
Citation
Breast Cancer Research, 2012, v. 14, p. R42 How to Cite?
AbstractINTRODUCTION: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers. METHODS: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer. RESULTS: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43). CONCLUSIONS: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.
Persistent Identifierhttp://hdl.handle.net/10722/251819
ISSN
2017 Impact Factor: 6.142
2015 SCImago Journal Rankings: 3.133
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKotsopoulos, J-
dc.contributor.authorLubinski, J-
dc.contributor.authorSalmena, L-
dc.contributor.authorLynch, HT-
dc.contributor.authorKim-Sing, C-
dc.contributor.authorFoulkes, WD-
dc.contributor.authorGhadirian, P-
dc.contributor.authorNeuhausen, SL-
dc.contributor.authorDemsky, R-
dc.contributor.authorTung, N-
dc.contributor.authorAinsworth, P-
dc.contributor.authorSenter, L-
dc.contributor.authorEisen, A-
dc.contributor.authorEng, C-
dc.contributor.authorSinger, C-
dc.contributor.authorGinsburg, O-
dc.contributor.authorBlum, J-
dc.contributor.authorHuzarski, T-
dc.contributor.authorPoll, A-
dc.contributor.authorSun, P-
dc.contributor.authorNarod, SA-
dc.contributor.authorKwong, A-
dc.date.accessioned2018-03-19T07:01:46Z-
dc.date.available2018-03-19T07:01:46Z-
dc.date.issued2012-
dc.identifier.citationBreast Cancer Research, 2012, v. 14, p. R42-
dc.identifier.issn1465-542X-
dc.identifier.urihttp://hdl.handle.net/10722/251819-
dc.description.abstractINTRODUCTION: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers. METHODS: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer. RESULTS: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43). CONCLUSIONS: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://breast-cancer-research.com/-
dc.relation.ispartofBreast Cancer Research-
dc.rightsBreast Cancer Research. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleBreastfeeding And The Risk Of Breast Cancer In Brca1 And Brca2 Mutation Carriers-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/bcr3138-
dc.identifier.hkuros284574-
dc.identifier.volume14-
dc.identifier.spageR42-
dc.identifier.epageR42-
dc.identifier.isiWOS:000304771800017-
dc.publisher.placeUnited Kingdom-

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