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- Publisher Website: 10.1007/s00330-017-5207-z
- Scopus: eid_2-s2.0-85051842137
- PMID: 29313120
- WOS: WOS:000431653200046
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Article: Significance of hyperechoic marks observed during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules
Title | Significance of hyperechoic marks observed during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules |
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Authors | |
Keywords | Ablation techniques High-intensity focused ultrasound ablation Induced hyperthermia Interventional ultrasonography Nodular goitre |
Issue Date | 2018 |
Publisher | Springer Berlin Heidelberg. The Journal's web site is located at https://link.springer.com/journal/330 |
Citation | European Radiology, 2018 How to Cite? |
Abstract | OBJECTIVE:
To examine the association between the appearance of hyperechoic marks (HEMs) during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules and nodule shrinkage at 6 months.
METHODS:
One hundred and thirty-six patients who underwent HIFU for benign thyroid nodule were analysed. An independent person carefully examined the B-mode ultrasonography screen for the appearance of HEMs after each pulse. The proportion of HEMs (%) was calculated by: [(Number of pulses that resulted in HEMs) / (Total number of pulses given per treatment) × 100] while the nodule shrinkage was measured by volume reduction ratio (VRR) = [Baseline volume-volume at 6 months]/[Baseline volume] * 100. Treatment success was defined as VRR ≥ 50 %.
RESULTS:
Patients with HEMs (n=91) had significantly greater 6-month VRR than those without HEMs (n=45) (65.76 % vs. 36.76 %, p<0.001). By regression analysis, after adjusting for age and energy per pulse, smaller nodule volume at baseline (OR 1.143, 95 % CI 1.038-1.256, p=0.006) and appearance of HEMs (OR 275.44, 95 % CI 26.63-2848.98, p<0.001) were independent predictors for treatment success.
CONCLUSIONS:
The appearance of HEMs during treatment was an independent determinant of treatment success following single-session HIFU ablation of benign thyroid nodule.
KEY POINTS:
• HIFU is a safe and effective treatment for benign thyroid nodules. • Lower BMI and greater applied power increase likelihood of hyperechoic marks. • The appearance of hyperechoic marks during HIFU affects subsequent treatment outcome. |
Persistent Identifier | http://hdl.handle.net/10722/251422 |
ISSN | 2021 Impact Factor: 7.034 2020 SCImago Journal Rankings: 1.606 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lang, HHB | - |
dc.contributor.author | Woo, YC | - |
dc.contributor.author | Chiu, WHK | - |
dc.date.accessioned | 2018-03-01T03:39:02Z | - |
dc.date.available | 2018-03-01T03:39:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | European Radiology, 2018 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | http://hdl.handle.net/10722/251422 | - |
dc.description.abstract | OBJECTIVE: To examine the association between the appearance of hyperechoic marks (HEMs) during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules and nodule shrinkage at 6 months. METHODS: One hundred and thirty-six patients who underwent HIFU for benign thyroid nodule were analysed. An independent person carefully examined the B-mode ultrasonography screen for the appearance of HEMs after each pulse. The proportion of HEMs (%) was calculated by: [(Number of pulses that resulted in HEMs) / (Total number of pulses given per treatment) × 100] while the nodule shrinkage was measured by volume reduction ratio (VRR) = [Baseline volume-volume at 6 months]/[Baseline volume] * 100. Treatment success was defined as VRR ≥ 50 %. RESULTS: Patients with HEMs (n=91) had significantly greater 6-month VRR than those without HEMs (n=45) (65.76 % vs. 36.76 %, p<0.001). By regression analysis, after adjusting for age and energy per pulse, smaller nodule volume at baseline (OR 1.143, 95 % CI 1.038-1.256, p=0.006) and appearance of HEMs (OR 275.44, 95 % CI 26.63-2848.98, p<0.001) were independent predictors for treatment success. CONCLUSIONS: The appearance of HEMs during treatment was an independent determinant of treatment success following single-session HIFU ablation of benign thyroid nodule. KEY POINTS: • HIFU is a safe and effective treatment for benign thyroid nodules. • Lower BMI and greater applied power increase likelihood of hyperechoic marks. • The appearance of hyperechoic marks during HIFU affects subsequent treatment outcome. | - |
dc.language | eng | - |
dc.publisher | Springer Berlin Heidelberg. The Journal's web site is located at https://link.springer.com/journal/330 | - |
dc.relation.ispartof | European Radiology | - |
dc.subject | Ablation techniques | - |
dc.subject | High-intensity focused ultrasound ablation | - |
dc.subject | Induced hyperthermia | - |
dc.subject | Interventional ultrasonography | - |
dc.subject | Nodular goitre | - |
dc.title | Significance of hyperechoic marks observed during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules | - |
dc.type | Article | - |
dc.identifier.email | Lang, HHB: Blang@hku.hk | - |
dc.identifier.email | Woo, YC: wooyucho@hku.hk | - |
dc.identifier.email | Chiu, WHK: kwhchiu@hku.hk | - |
dc.identifier.authority | Lang, HHB=rp01828 | - |
dc.identifier.authority | Chiu, WHK=rp02074 | - |
dc.identifier.doi | 10.1007/s00330-017-5207-z | - |
dc.identifier.pmid | 29313120 | - |
dc.identifier.scopus | eid_2-s2.0-85051842137 | - |
dc.identifier.hkuros | 284081 | - |
dc.identifier.volume | Epub ahead of print | - |
dc.identifier.isi | WOS:000431653200046 | - |
dc.publisher.place | Ireland | - |
dc.identifier.issnl | 0938-7994 | - |