File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Genetically predicted 17β-estradiol and systemic inflammation in women: A separate-sample Mendelian randomisation analysis in the Guangzhou Biobank cohort study

TitleGenetically predicted 17β-estradiol and systemic inflammation in women: A separate-sample Mendelian randomisation analysis in the Guangzhou Biobank cohort study
Authors
Issue Date2014
Citation
Journal of Epidemiology and Community Health, 2014, v. 68, n. 8, p. 780-785 How to Cite?
AbstractBackground: Many chronic diseases are characterised by low-grade systemic inflammation. Oestrogens may promote immune response consistent with sex-specific patterns of diseases. In vitro culture and animal experiments suggest oestrogens are anti-inf lammatory and might thereby protect against low-grade systemic inflammation. Evidence from epidemiological studies is limited. Using a Mendelian randomisation analysis with a separate-sample instrumental variable (SSIV) estimator, we examined the association of genetically predicted 17β-estradiol with well-established systemic inflammatory markers (total white cell count, granulocyte and lymphocyte count). Methods: A genetic score predicting 17β-estradiol was developed in 237 young Chinese women (university students) from Hong Kong based on a parsimonious set of genetic polymorphisms (ESR1 (rs2175898) and CYP19A1 (rs1008805)). Multivariable linear regression was used to examine the association of genetically predicted 17β-estradiol with systemic inflammatory markers among 3096 older (50+ years) Chinese women from the Guangzhou Biobank Cohort Study. Results: Predicted 17β-estradiol was negatively associated with white blood cell count (-6.3 103/mL, 95% CI -11.4 to -1.3) and granulocyte count (-4.5 10 3 /mL, 95% CI -8.5 to -0.4) but not lymphocyte count (-1.5 10 3 /mL, 95% CI -3.4 to 0.4) adjusted for age only. Results were similar further adjusted for education, smoking, use of alcohol, physical activity, Body Mass Index, waist-hip ratio, age of menarche, age at menopause, use of hormonal contraceptives and hormone replacement therapy. Conclusions: Endogenous genetically predicted 17β-estradiol reduced low-grade systemic inflammatory markers (white blood cell count and granulocyte count), consistent with experimental and ecological evidence of 17β-estradiol promoting immune response. Replication in a larger sample is required.
Persistent Identifierhttp://hdl.handle.net/10722/249723
ISSN
2017 Impact Factor: 3.973
2015 SCImago Journal Rankings: 1.890
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, J.-
dc.contributor.authorJiang, C. Q.-
dc.contributor.authorLam, T. H.-
dc.contributor.authorLiu, B.-
dc.contributor.authorCheng, K. K.-
dc.contributor.authorKavikondala, S.-
dc.contributor.authorZhang, W. S.-
dc.contributor.authorLeung, G. M.-
dc.contributor.authorSchooling, C. M.-
dc.date.accessioned2017-11-28T02:13:06Z-
dc.date.available2017-11-28T02:13:06Z-
dc.date.issued2014-
dc.identifier.citationJournal of Epidemiology and Community Health, 2014, v. 68, n. 8, p. 780-785-
dc.identifier.issn0143-005X-
dc.identifier.urihttp://hdl.handle.net/10722/249723-
dc.description.abstractBackground: Many chronic diseases are characterised by low-grade systemic inflammation. Oestrogens may promote immune response consistent with sex-specific patterns of diseases. In vitro culture and animal experiments suggest oestrogens are anti-inf lammatory and might thereby protect against low-grade systemic inflammation. Evidence from epidemiological studies is limited. Using a Mendelian randomisation analysis with a separate-sample instrumental variable (SSIV) estimator, we examined the association of genetically predicted 17β-estradiol with well-established systemic inflammatory markers (total white cell count, granulocyte and lymphocyte count). Methods: A genetic score predicting 17β-estradiol was developed in 237 young Chinese women (university students) from Hong Kong based on a parsimonious set of genetic polymorphisms (ESR1 (rs2175898) and CYP19A1 (rs1008805)). Multivariable linear regression was used to examine the association of genetically predicted 17β-estradiol with systemic inflammatory markers among 3096 older (50+ years) Chinese women from the Guangzhou Biobank Cohort Study. Results: Predicted 17β-estradiol was negatively associated with white blood cell count (-6.3 103/mL, 95% CI -11.4 to -1.3) and granulocyte count (-4.5 10 3 /mL, 95% CI -8.5 to -0.4) but not lymphocyte count (-1.5 10 3 /mL, 95% CI -3.4 to 0.4) adjusted for age only. Results were similar further adjusted for education, smoking, use of alcohol, physical activity, Body Mass Index, waist-hip ratio, age of menarche, age at menopause, use of hormonal contraceptives and hormone replacement therapy. Conclusions: Endogenous genetically predicted 17β-estradiol reduced low-grade systemic inflammatory markers (white blood cell count and granulocyte count), consistent with experimental and ecological evidence of 17β-estradiol promoting immune response. Replication in a larger sample is required.-
dc.languageeng-
dc.relation.ispartofJournal of Epidemiology and Community Health-
dc.titleGenetically predicted 17β-estradiol and systemic inflammation in women: A separate-sample Mendelian randomisation analysis in the Guangzhou Biobank cohort study-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1136/jech-2013-203451-
dc.identifier.pmid24737458-
dc.identifier.scopuseid_2-s2.0-84904185092-
dc.identifier.hkuros230833-
dc.identifier.volume68-
dc.identifier.issue8-
dc.identifier.spage780-
dc.identifier.epage785-
dc.identifier.eissn1470-2738-
dc.identifier.isiWOS:000339723200015-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats