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Article: N1 Amplitude of Auditory Evoked Potentials and Spontaneous Functional Connectivity between Bilateral Heschl's Gyrus are Coupled at Inter-individual Level

TitleN1 Amplitude of Auditory Evoked Potentials and Spontaneous Functional Connectivity between Bilateral Heschl's Gyrus are Coupled at Inter-individual Level
Authors
Issue Date2016
PublisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/overview/brain-connectivity/389/
Citation
Brain Connectivity, 2016, v. 6 n. 6, p. 496-504 How to Cite?
AbstractN1 component of auditory evoked potentials is extensively used to investigate the propagation and processing of auditory inputs. However, the substantial interindividual variability of N1 could be a possible confounding factor when comparing different individuals or groups. Therefore, identifying the neuronal mechanism and origin of the interindividual variability of N1 is crucial in basic research and clinical applications. This study is aimed to use simultaneously recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data to investigate the coupling between N1 and spontaneous functional connectivity (FC). EEG and fMRI data were simultaneously collected from a group of healthy individuals during a pure-tone listening task. Spontaneous FC was estimated from spontaneous blood oxygenation level-dependent (BOLD) signals that were isolated by regressing out task evoked BOLD signals from raw BOLD signals and then was correlated to N1 magnitude across individuals. It was observed that spontaneous FC between bilateral Heschl's gyrus was significantly and positively correlated with N1 magnitude across individuals (Spearman's R = 0.829, p < 0.001). The specificity of this observation was further confirmed by two whole-brain voxelwise analyses (voxel-mirrored homotopic connectivity analysis and seed-based connectivity analysis). These results enriched our understanding of the functional significance of the coupling between event-related brain responses and spontaneous brain connectivity, and hold the potential to increase the applicability of brain responses as a probe to the mechanism underlying pathophysiological conditions.
Persistent Identifierhttp://hdl.handle.net/10722/249491
ISSN
2015 SCImago Journal Rankings: 1.429
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTAN, A-
dc.contributor.authorHu, L-
dc.contributor.authorTU, Y-
dc.contributor.authorChen, R-
dc.contributor.authorHung, YS-
dc.contributor.authorZhang, Z-
dc.date.accessioned2017-11-21T03:02:59Z-
dc.date.available2017-11-21T03:02:59Z-
dc.date.issued2016-
dc.identifier.citationBrain Connectivity, 2016, v. 6 n. 6, p. 496-504-
dc.identifier.issn2158-0014-
dc.identifier.urihttp://hdl.handle.net/10722/249491-
dc.description.abstractN1 component of auditory evoked potentials is extensively used to investigate the propagation and processing of auditory inputs. However, the substantial interindividual variability of N1 could be a possible confounding factor when comparing different individuals or groups. Therefore, identifying the neuronal mechanism and origin of the interindividual variability of N1 is crucial in basic research and clinical applications. This study is aimed to use simultaneously recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data to investigate the coupling between N1 and spontaneous functional connectivity (FC). EEG and fMRI data were simultaneously collected from a group of healthy individuals during a pure-tone listening task. Spontaneous FC was estimated from spontaneous blood oxygenation level-dependent (BOLD) signals that were isolated by regressing out task evoked BOLD signals from raw BOLD signals and then was correlated to N1 magnitude across individuals. It was observed that spontaneous FC between bilateral Heschl's gyrus was significantly and positively correlated with N1 magnitude across individuals (Spearman's R = 0.829, p < 0.001). The specificity of this observation was further confirmed by two whole-brain voxelwise analyses (voxel-mirrored homotopic connectivity analysis and seed-based connectivity analysis). These results enriched our understanding of the functional significance of the coupling between event-related brain responses and spontaneous brain connectivity, and hold the potential to increase the applicability of brain responses as a probe to the mechanism underlying pathophysiological conditions.-
dc.languageeng-
dc.publisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/overview/brain-connectivity/389/-
dc.relation.ispartofBrain Connectivity-
dc.rightsBrain Connectivity. Copyright © Mary Ann Liebert, Inc. Publishers.-
dc.rightsFinal publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/[insert DOI]-
dc.titleN1 Amplitude of Auditory Evoked Potentials and Spontaneous Functional Connectivity between Bilateral Heschl's Gyrus are Coupled at Inter-individual Level-
dc.typeArticle-
dc.identifier.emailHung, YS: yshung@hkucc.hku.hk-
dc.identifier.emailZhang, Z: zhangzg@hku.hk-
dc.identifier.authorityHung, YS=rp00220-
dc.identifier.authorityZhang, Z=rp01565-
dc.identifier.doi10.1089/brain.2016.0418-
dc.identifier.hkuros282954-
dc.identifier.volume6-
dc.identifier.issue6-
dc.identifier.spage496-
dc.identifier.epage504-
dc.identifier.isiWOS:000448209600006-
dc.publisher.placeUnited States-

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