File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion

TitleReprogramming of T cells to natural killer-like cells upon Bcl11b deletion
Authors
Issue Date2010
Citation
Science, 2010, v. 329, n. 5987, p. 85-89 How to Cite?
AbstractT cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune system in tumor surveillance, reproduction, and defense against microbes and viruses. Here, we show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies. Copyright 2010 by the American Association for the Advancement of Science; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/249147
ISSN
2017 Impact Factor: 41.058
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Peng-
dc.contributor.authorBurke, Shannon-
dc.contributor.authorWang, Juexuan-
dc.contributor.authorChen, Xiongfeng-
dc.contributor.authorOrtiz, Mariaestela-
dc.contributor.authorLee, Song Choon-
dc.contributor.authorLu, Dong-
dc.contributor.authorCampos, Lia-
dc.contributor.authorGoulding, David-
dc.contributor.authorNg, Bee Ling-
dc.contributor.authorDougan, Gordon-
dc.contributor.authorHuntly, Brian-
dc.contributor.authorGottgens, Bertie-
dc.contributor.authorJenkins, Nancy A.-
dc.contributor.authorCopeland, Neal G.-
dc.contributor.authorColucci, Francesco-
dc.contributor.authorLiu, Pentao-
dc.date.accessioned2017-10-27T05:59:13Z-
dc.date.available2017-10-27T05:59:13Z-
dc.date.issued2010-
dc.identifier.citationScience, 2010, v. 329, n. 5987, p. 85-89-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/249147-
dc.description.abstractT cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune system in tumor surveillance, reproduction, and defense against microbes and viruses. Here, we show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies. Copyright 2010 by the American Association for the Advancement of Science; all rights reserved.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleReprogramming of T cells to natural killer-like cells upon Bcl11b deletion-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.1188063-
dc.identifier.pmid20538915-
dc.identifier.scopuseid_2-s2.0-77954326626-
dc.identifier.volume329-
dc.identifier.issue5987-
dc.identifier.spage85-
dc.identifier.epage89-
dc.identifier.eissn1095-9203-
dc.identifier.isiWOS:000279402700038-
dc.identifier.f10003566956-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats