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Article: Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

TitleHeterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
Authors
KeywordsXenografts
B-ALL
Heterogeneity
Leukemia stem cell
Issue Date2016
Citation
Journal of Hematology and Oncology, 2016, v. 9, n. 1, p. 1-5 How to Cite?
Abstract© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.
Persistent Identifierhttp://hdl.handle.net/10722/249132
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, Zhiwu-
dc.contributor.authorDeng, Manman-
dc.contributor.authorWei, Xinru-
dc.contributor.authorYe, Wei-
dc.contributor.authorXiao, Yiren-
dc.contributor.authorLin, Simiao-
dc.contributor.authorWang, Suna-
dc.contributor.authorLi, Baiheng-
dc.contributor.authorLiu, Xin-
dc.contributor.authorZhang, Gong-
dc.contributor.authorLai, Peilong-
dc.contributor.authorWeng, Jianyu-
dc.contributor.authorWu, Donghai-
dc.contributor.authorChen, Haijia-
dc.contributor.authorWei, Wei-
dc.contributor.authorMa, Yuguo-
dc.contributor.authorLi, Yangqiu-
dc.contributor.authorLiu, Pentao-
dc.contributor.authorDu, Xin-
dc.contributor.authorPei, Duanqing-
dc.contributor.authorYao, Yao-
dc.contributor.authorXu, Bing-
dc.contributor.authorLi, Peng-
dc.date.accessioned2017-10-27T05:59:11Z-
dc.date.available2017-10-27T05:59:11Z-
dc.date.issued2016-
dc.identifier.citationJournal of Hematology and Oncology, 2016, v. 9, n. 1, p. 1-5-
dc.identifier.urihttp://hdl.handle.net/10722/249132-
dc.description.abstract© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.-
dc.languageeng-
dc.relation.ispartofJournal of Hematology and Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectXenografts-
dc.subjectB-ALL-
dc.subjectHeterogeneity-
dc.subjectLeukemia stem cell-
dc.titleHeterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13045-016-0310-1-
dc.identifier.scopuseid_2-s2.0-84994853761-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.spage1-
dc.identifier.epage5-
dc.identifier.eissn1756-8722-
dc.identifier.isiWOS:000383951000002-

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