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Article: Polygenic in vivo validation of cancer mutations using transposons

TitlePolygenic in vivo validation of cancer mutations using transposons
Authors
Issue Date2014
Citation
Genome biology, 2014, v. 15, n. 9, p. 455 How to Cite?
AbstractThe in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows multiple cancer mutations to be validated in each animal line. Animal lines are generated with multiple candidate cancer mutations using transposons. The candidate cancer genes are tagged and randomly expressed in somatic cells, allowing easy identification of the cancer genes involved in the generated tumours. This system presents a useful, generalised and efficient means for animal validation of cancer genes.
Persistent Identifierhttp://hdl.handle.net/10722/249125

 

DC FieldValueLanguage
dc.contributor.authorChew, Su K it-
dc.contributor.authorLu, Dong-
dc.contributor.authorCampos, Lia S.-
dc.contributor.authorScott, Kenneth L.-
dc.contributor.authorSaci, Abdel-
dc.contributor.authorWang, Juexuan-
dc.contributor.authorCollinson, Adam-
dc.contributor.authorRaine, Keiran-
dc.contributor.authorHinton, Jonathan-
dc.contributor.authorTeague, Jon W.-
dc.contributor.authorJones, David-
dc.contributor.authorMenzies, Andrew-
dc.contributor.authorButler, Adam P.-
dc.contributor.authorGamble, John-
dc.contributor.authorO'Meara, Sarah-
dc.contributor.authorMcLaren, Stuart-
dc.contributor.authorChin, Lynda-
dc.contributor.authorLiu, Pentao-
dc.contributor.authorFutreal, P. Andrew-
dc.date.accessioned2017-10-27T05:59:10Z-
dc.date.available2017-10-27T05:59:10Z-
dc.date.issued2014-
dc.identifier.citationGenome biology, 2014, v. 15, n. 9, p. 455-
dc.identifier.urihttp://hdl.handle.net/10722/249125-
dc.description.abstractThe in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows multiple cancer mutations to be validated in each animal line. Animal lines are generated with multiple candidate cancer mutations using transposons. The candidate cancer genes are tagged and randomly expressed in somatic cells, allowing easy identification of the cancer genes involved in the generated tumours. This system presents a useful, generalised and efficient means for animal validation of cancer genes.-
dc.languageeng-
dc.relation.ispartofGenome biology-
dc.titlePolygenic in vivo validation of cancer mutations using transposons-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1186/s13059-014-0455-6-
dc.identifier.pmid25260652-
dc.identifier.scopuseid_2-s2.0-84965184730-
dc.identifier.volume15-
dc.identifier.issue9-
dc.identifier.spage455-
dc.identifier.epage-
dc.identifier.eissn1474-760X-

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