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Article: Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells

TitleLoss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells
Authors
KeywordsRepopulation
Knockout-mice
Homing
Hematopoietic stem cell
Angptl7
Issue Date2015
Citation
Journal of Hematology and Oncology, 2015, v. 8, n. 1 How to Cite?
Abstract© 2015 Xiao et al.; licensee Biomed Central. Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner.
Persistent Identifierhttp://hdl.handle.net/10722/249103
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiao, Yiren-
dc.contributor.authorWei, Xinru-
dc.contributor.authorJiang, Zhiwu-
dc.contributor.authorWang, Xiangmeng-
dc.contributor.authorYe, Wei-
dc.contributor.authorLiu, Xin-
dc.contributor.authorZhang, Minjie-
dc.contributor.authorXu, Yan-
dc.contributor.authorWu, Donghai-
dc.contributor.authorLai, Liangxue-
dc.contributor.authorYao, Huihui-
dc.contributor.authorLiu, Zixia-
dc.contributor.authorCao, Su-
dc.contributor.authorLiu, Pentao-
dc.contributor.authorXu, Bing-
dc.contributor.authorLi, Yangqiu-
dc.contributor.authorYao, Yao-
dc.contributor.authorPei, Duanqing-
dc.contributor.authorLi, Peng-
dc.date.accessioned2017-10-27T05:59:07Z-
dc.date.available2017-10-27T05:59:07Z-
dc.date.issued2015-
dc.identifier.citationJournal of Hematology and Oncology, 2015, v. 8, n. 1-
dc.identifier.urihttp://hdl.handle.net/10722/249103-
dc.description.abstract© 2015 Xiao et al.; licensee Biomed Central. Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner.-
dc.languageeng-
dc.relation.ispartofJournal of Hematology and Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectRepopulation-
dc.subjectKnockout-mice-
dc.subjectHoming-
dc.subjectHematopoietic stem cell-
dc.subjectAngptl7-
dc.titleLoss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13045-014-0102-4-
dc.identifier.pmid25652910-
dc.identifier.scopuseid_2-s2.0-84925382634-
dc.identifier.volume8-
dc.identifier.issue1-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1756-8722-
dc.identifier.isiWOS:000350952000001-

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