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Article: Cellular reprogramming by transcription factor engineering

TitleCellular reprogramming by transcription factor engineering
Authors
Tsang, Jason C.H.Gao, XuefeiLu, LimingLiu, Pentao
Issue Date2014
Citation
Current Opinion in Genetics and Development, 2014, v. 28, p. 1-9 How to Cite?
DOI: http://dx.doi.org/10.1016/j.gde.2014.07.001
AbstractRecent researches have identified multiple transcription factors as permissible reprogramming factors to pluripotency and lineage switching. The current standard strategy by ectopic factor overexpression however has intrinsic limitations in studying the reprogramming mechanism. There is a growing interest in engineering novel chimeric reprogramming factors and applying designer transcription factors technology to improve reprogramming efficiency and dissect the process of endogenous pluripotency network reactivation. Here, we provide a concise review on the latest progress in studying cellular reprogramming by transcription factor engineering. © 2014 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/249098
ISSN
0959-437X
2021 Impact Factor: 4.665
2020 SCImago Journal Rankings: 3.407
ISI Accession Number ID
WOS:000347764300002

 

DC FieldValueLanguage
dc.contributor.authorTsang, Jason C.H.-
dc.contributor.authorGao, Xuefei-
dc.contributor.authorLu, Liming-
dc.contributor.authorLiu, Pentao-
dc.date.accessioned2017-10-27T05:59:06Z-
dc.date.available2017-10-27T05:59:06Z-
dc.date.issued2014-
dc.identifier.citationCurrent Opinion in Genetics and Development, 2014, v. 28, p. 1-9-
dc.identifier.issn0959-437X-
dc.identifier.urihttp://hdl.handle.net/10722/249098-
dc.description.abstractRecent researches have identified multiple transcription factors as permissible reprogramming factors to pluripotency and lineage switching. The current standard strategy by ectopic factor overexpression however has intrinsic limitations in studying the reprogramming mechanism. There is a growing interest in engineering novel chimeric reprogramming factors and applying designer transcription factors technology to improve reprogramming efficiency and dissect the process of endogenous pluripotency network reactivation. Here, we provide a concise review on the latest progress in studying cellular reprogramming by transcription factor engineering. © 2014 Elsevier Ltd.-
dc.languageeng-
dc.relation.ispartofCurrent Opinion in Genetics and Development-
dc.titleCellular reprogramming by transcription factor engineering-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.gde.2014.07.001-
dc.identifier.pmid25151337-
dc.identifier.scopuseid_2-s2.0-84906346041-
dc.identifier.volume28-
dc.identifier.spage1-
dc.identifier.epage9-
dc.identifier.eissn1879-0380-
dc.identifier.isiWOS:000347764300002-
dc.identifier.issnl0959-437X-

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