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- Publisher Website: 10.1046/j.1365-2184.35.s1.12.x
- Scopus: eid_2-s2.0-0036366856
- PMID: 12139714
- WOS: WOS:000177033600013
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Article: Epithelial cell proliferative activity and oral cancer progression
Title | Epithelial cell proliferative activity and oral cancer progression |
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Authors | |
Keywords | Histone mRNA Cyclin A labelling Oral squamous cell carcinoma Oral dysplasia Clinical outcome Oral cancer Ki67 labelling |
Issue Date | 2002 |
Citation | Cell Proliferation, 2002, v. 35, n. SUPPL. 1, p. 110-120 How to Cite? |
Abstract | Accurate, predictive assessment of the behaviour and progression of oral cancers and precancers remains elusive in clinical practice. Archival tissue specimens from 10 previously treated patients with oral lesions of known clinical outcome (3 years post-treatment) were re-examined histopathologically, and proliferative cell labelling indices (LIs) determined for Ki67, cyclin A and histone mRNA cell cycle markers. While histone mRNA labelling ultimately proved unreliable, both Ki67 and cyclin A LIs demonstrated a clear trend for enhanced labelling to occur in increasingly dysplastic and neoplastic tissue, with particular emphasis on suprabasal labelling in abnormal tissue. Perhaps of greatest significance was the observation of increased LIs and suprabasal labelling in lesions with poor clinical outcome, such as patients developing recurrent disease or cervical lymph node metastasis. Measurement of cell proliferative activity in individual oral epithelial dysplastic lesions or invasive squamous cell carcinomas may thus provide unique, predictive information on clinical outcome. |
Persistent Identifier | http://hdl.handle.net/10722/249003 |
ISSN | 2021 Impact Factor: 8.755 2020 SCImago Journal Rankings: 1.647 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Thomson, P. J. | - |
dc.contributor.author | Soames, J. V. | - |
dc.contributor.author | Booth, C. | - |
dc.contributor.author | O'Shea, J. A. | - |
dc.date.accessioned | 2017-10-27T05:58:51Z | - |
dc.date.available | 2017-10-27T05:58:51Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Cell Proliferation, 2002, v. 35, n. SUPPL. 1, p. 110-120 | - |
dc.identifier.issn | 0960-7722 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249003 | - |
dc.description.abstract | Accurate, predictive assessment of the behaviour and progression of oral cancers and precancers remains elusive in clinical practice. Archival tissue specimens from 10 previously treated patients with oral lesions of known clinical outcome (3 years post-treatment) were re-examined histopathologically, and proliferative cell labelling indices (LIs) determined for Ki67, cyclin A and histone mRNA cell cycle markers. While histone mRNA labelling ultimately proved unreliable, both Ki67 and cyclin A LIs demonstrated a clear trend for enhanced labelling to occur in increasingly dysplastic and neoplastic tissue, with particular emphasis on suprabasal labelling in abnormal tissue. Perhaps of greatest significance was the observation of increased LIs and suprabasal labelling in lesions with poor clinical outcome, such as patients developing recurrent disease or cervical lymph node metastasis. Measurement of cell proliferative activity in individual oral epithelial dysplastic lesions or invasive squamous cell carcinomas may thus provide unique, predictive information on clinical outcome. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Proliferation | - |
dc.subject | Histone mRNA | - |
dc.subject | Cyclin A labelling | - |
dc.subject | Oral squamous cell carcinoma | - |
dc.subject | Oral dysplasia | - |
dc.subject | Clinical outcome | - |
dc.subject | Oral cancer | - |
dc.subject | Ki67 labelling | - |
dc.title | Epithelial cell proliferative activity and oral cancer progression | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1046/j.1365-2184.35.s1.12.x | - |
dc.identifier.pmid | 12139714 | - |
dc.identifier.scopus | eid_2-s2.0-0036366856 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | SUPPL. 1 | - |
dc.identifier.spage | 110 | - |
dc.identifier.epage | 120 | - |
dc.identifier.isi | WOS:000177033600013 | - |
dc.identifier.issnl | 0960-7722 | - |