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Article: The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

TitleThe transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Authors
Issue Date2015
Citation
Journal of Experimental Medicine, 2015, v. 212, n. 6, p. 865-874 How to Cite?
Abstract© 2015 Yu et al. Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ~28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
Persistent Identifierhttp://hdl.handle.net/10722/248983
ISSN
2015 Impact Factor: 11.24
2015 SCImago Journal Rankings: 10.762

 

DC FieldValueLanguage
dc.contributor.authorYu, Yong-
dc.contributor.authorWang, Cui-
dc.contributor.authorClare, Simon-
dc.contributor.authorWang, Juexuan-
dc.contributor.authorLee, Song Choon-
dc.contributor.authorBrandt, Cordelia-
dc.contributor.authorBurke, Shannon-
dc.contributor.authorLu, Liming-
dc.contributor.authorHe, Daqian-
dc.contributor.authorJenkins, Nancy A.-
dc.contributor.authorCopeland, Neal G.-
dc.contributor.authorDougan, Gordon-
dc.contributor.authorLiu, Pentao-
dc.date.accessioned2017-10-27T05:58:47Z-
dc.date.available2017-10-27T05:58:47Z-
dc.date.issued2015-
dc.identifier.citationJournal of Experimental Medicine, 2015, v. 212, n. 6, p. 865-874-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/248983-
dc.description.abstract© 2015 Yu et al. Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ~28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleThe transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1084/jem.20142318-
dc.identifier.pmid25964371-
dc.identifier.scopuseid_2-s2.0-84980390670-
dc.identifier.volume212-
dc.identifier.issue6-
dc.identifier.spage865-
dc.identifier.epage874-
dc.identifier.eissn1540-9538-

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