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Article: Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy

TitleNovel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy
Authors
Issue Date2016
PublisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2016, v. 6, p. 35781  How to Cite?
AbstractKnown susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci based on GWAS on Chinese populations. The more recent study with high-density genotyping of immune-related loci in individuals with Asian ancestry identified 10 new and 6 suggestive loci in SLE. In the current study, we thus included all the lead SNPs from these 16 loci reported, and firstly tested their associations in 1,248 patients with sporadic IgAN, 737 patients with LN and 1,187 controls. Significant associations identified in IgAN were replicated in additional 500 patients and 2372 controls. rs12022418 in RGS1 (p = 3.0 × 10-6) and rs7170151 in RASGRP1 (p = 1.9 × 10-5) showed novel associations in IgAN. Compared to SNPs that were in LD with them, the associated variants showed higher potential of regulatory features by affecting gene expression. And systemic evaluation of GWAS data supported the pleiotropic effects of RGS1 and RASGRP1 variants in mediating human complex diseases. In conclusion, novel risk loci shared between IgAN and SLE/LN were identified, which may shed new light to exploit the potential pathogenesis for those two diseases.
Persistent Identifierhttp://hdl.handle.net/10722/248485
ISSN
2017 Impact Factor: 4.122
2015 SCImago Journal Rankings: 2.073
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, XJ-
dc.contributor.authorNath, SK-
dc.contributor.authorQi, YY-
dc.contributor.authorSun, C-
dc.contributor.authorHou, P-
dc.contributor.authorZhang, YM-
dc.contributor.authorLv, JC-
dc.contributor.authorShi, SF-
dc.contributor.authorLiu, LJ-
dc.contributor.authorCHEN, R-
dc.contributor.authorYang, W-
dc.contributor.authorHe, KZ-
dc.contributor.authorLi, Y-
dc.contributor.authorZhang, H-
dc.date.accessioned2017-10-18T08:43:56Z-
dc.date.available2017-10-18T08:43:56Z-
dc.date.issued2016-
dc.identifier.citationScientific Reports, 2016, v. 6, p. 35781 -
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/248485-
dc.description.abstractKnown susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci based on GWAS on Chinese populations. The more recent study with high-density genotyping of immune-related loci in individuals with Asian ancestry identified 10 new and 6 suggestive loci in SLE. In the current study, we thus included all the lead SNPs from these 16 loci reported, and firstly tested their associations in 1,248 patients with sporadic IgAN, 737 patients with LN and 1,187 controls. Significant associations identified in IgAN were replicated in additional 500 patients and 2372 controls. rs12022418 in RGS1 (p = 3.0 × 10-6) and rs7170151 in RASGRP1 (p = 1.9 × 10-5) showed novel associations in IgAN. Compared to SNPs that were in LD with them, the associated variants showed higher potential of regulatory features by affecting gene expression. And systemic evaluation of GWAS data supported the pleiotropic effects of RGS1 and RASGRP1 variants in mediating human complex diseases. In conclusion, novel risk loci shared between IgAN and SLE/LN were identified, which may shed new light to exploit the potential pathogenesis for those two diseases.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleNovel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy-
dc.typeArticle-
dc.identifier.emailYang, W: yangwl@hkucc.hku.hk-
dc.identifier.authorityYang, W=rp00524-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep35781-
dc.identifier.hkuros280938-
dc.identifier.volume6-
dc.identifier.spage35781-
dc.identifier.epage35781-
dc.identifier.isiWOS:000386724600001-
dc.publisher.placeUnited Kingdom-

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