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Article: Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma

TitleNfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma
Authors
Issue Date2017
PublishereLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/
Citation
eLife, 2017, v. 6, p. e26733 How to Cite?
AbstractTumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high NFATc2 expression predicted poor tumor differentiation, adverse recurrence-free and cancer-specific overall survivals. Mechanistic investigations identified NFATc2 response elements in the 3' enhancer region of SOX2, and NFATc2/SOX2 coupling upregulates ALDH1A1 by binding to its 5' enhancer. Through this axis, oxidative stress induced by cancer drug treatment is attenuated, leading to increased resistance in a mutation-independent manner. Targeting this axis provides a novel approach for the long-term treatment of lung cancer through TIC elimination.
Persistent Identifierhttp://hdl.handle.net/10722/247669
ISSN
2017 Impact Factor: 7.616
2015 SCImago Journal Rankings: 6.356

 

DC FieldValueLanguage
dc.contributor.authorXiao, Z-
dc.contributor.authorLiu, J-
dc.contributor.authorWANG, S-
dc.contributor.authorZHU, Y-
dc.contributor.authorGAO, X-
dc.contributor.authorQin, J-
dc.contributor.authorWang, J-
dc.contributor.authorWong, MP-
dc.date.accessioned2017-10-18T08:30:45Z-
dc.date.available2017-10-18T08:30:45Z-
dc.date.issued2017-
dc.identifier.citationeLife, 2017, v. 6, p. e26733-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/10722/247669-
dc.description.abstractTumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high NFATc2 expression predicted poor tumor differentiation, adverse recurrence-free and cancer-specific overall survivals. Mechanistic investigations identified NFATc2 response elements in the 3' enhancer region of SOX2, and NFATc2/SOX2 coupling upregulates ALDH1A1 by binding to its 5' enhancer. Through this axis, oxidative stress induced by cancer drug treatment is attenuated, leading to increased resistance in a mutation-independent manner. Targeting this axis provides a novel approach for the long-term treatment of lung cancer through TIC elimination.-
dc.languageeng-
dc.publishereLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/-
dc.relation.ispartofeLife-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleNfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma-
dc.typeArticle-
dc.identifier.emailXiao, Z: xiaozj@hku.hk-
dc.identifier.emailLiu, J: jingliue@hku.hk-
dc.identifier.emailWong, MP: mwpik@hku.hk-
dc.identifier.authorityWong, MP=rp00348-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7554/eLife.26733-
dc.identifier.hkuros280919-
dc.identifier.volume6-
dc.identifier.spagee26733-
dc.identifier.epagee26733-
dc.publisher.placeCambridge, UK-

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