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Article: Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model

TitleImmunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model
Authors
KeywordsAdsA
S. aureus
Adenosine synthase A
Immunotherapy
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2017, v. 216, p. 245-253 How to Cite?
AbstractStaphylococcusaureus is a severe pathogen found in the community and in hospitals. Most notably, methicillin-resistant S. aureus (MRSA) is resistant to almost all antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. Previous research showed that S. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. In this study, we investigated adenosine synthase A (AdsA), an S. aureus cell wall-anchored enzyme as possible targets for immunotherapy. Mice vaccinated with aluminum hydroxide-formulated recombinant AdsA (rAdsA) induced high-titer anti-AdsA antibodies, thereby providing consistent protection in 3 mouse infection models when challenged with 2 S. aureus strains. The importance of anti-AdsA antibody in protection was demonstrated by passive transfer experiments. Moreover, AdsA-specific antisera promote killing S. aureus by immune cells. Altogether, our data demonstrate that the AdsA is a promising target for vaccines and therapeutics development to alleviate severe S. aureus diseases.
Persistent Identifierhttp://hdl.handle.net/10722/246929
ISSN
2017 Impact Factor: 5.186
2015 SCImago Journal Rankings: 4.000
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, B-
dc.contributor.authorCai, J-
dc.contributor.authorYu, B-
dc.contributor.authorXiong, L-
dc.contributor.authorLin, Q-
dc.contributor.authorYang, X-
dc.contributor.authorXu, C-
dc.contributor.authorZheng, S-
dc.contributor.authorKao, RYT-
dc.contributor.authorSze, KH-
dc.contributor.authorYuen, KY-
dc.contributor.authorHuang, J-
dc.date.accessioned2017-10-18T08:19:32Z-
dc.date.available2017-10-18T08:19:32Z-
dc.date.issued2017-
dc.identifier.citationJournal of Infectious Diseases, 2017, v. 216, p. 245-253-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/246929-
dc.description.abstractStaphylococcusaureus is a severe pathogen found in the community and in hospitals. Most notably, methicillin-resistant S. aureus (MRSA) is resistant to almost all antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. Previous research showed that S. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. In this study, we investigated adenosine synthase A (AdsA), an S. aureus cell wall-anchored enzyme as possible targets for immunotherapy. Mice vaccinated with aluminum hydroxide-formulated recombinant AdsA (rAdsA) induced high-titer anti-AdsA antibodies, thereby providing consistent protection in 3 mouse infection models when challenged with 2 S. aureus strains. The importance of anti-AdsA antibody in protection was demonstrated by passive transfer experiments. Moreover, AdsA-specific antisera promote killing S. aureus by immune cells. Altogether, our data demonstrate that the AdsA is a promising target for vaccines and therapeutics development to alleviate severe S. aureus diseases.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/-
dc.relation.ispartofJournal of Infectious Diseases-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdsA-
dc.subjectS. aureus-
dc.subjectAdenosine synthase A-
dc.subjectImmunotherapy-
dc.titleImmunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model-
dc.typeArticle-
dc.identifier.emailCai, J: caijuice@hku.hk-
dc.identifier.emailYu, B: ppayubin@hku.hk-
dc.identifier.emailXiong, L: lfxiong@hku.hk-
dc.identifier.emailLin, Q: qiubin@hku.hk-
dc.identifier.emailKao, RYT: rytkao@hkucc.hku.hk-
dc.identifier.emailSze, KH: khsze@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailHuang, J: jdhuang@hku.hk-
dc.identifier.authorityKao, RYT=rp00481-
dc.identifier.authoritySze, KH=rp00785-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityHuang, J=rp00451-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/infdis/jix290-
dc.identifier.pmid28633319-
dc.identifier.pmcidPMC5853884-
dc.identifier.scopuseid_2-s2.0-85028373339-
dc.identifier.hkuros280028-
dc.identifier.hkuros293486-
dc.identifier.volume216-
dc.identifier.spage245-
dc.identifier.epage253-
dc.identifier.isiWOS:000406832000014-
dc.publisher.placeUnited States-

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