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Article: Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy

TitleOvercoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy
Authors
Issue Date2014
PublishereLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/
Citation
eLife, 2014, v. 3, p. e03445:1-17 How to Cite?
AbstractActivating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and myelosuppression attributed to a 'synthetic lethal toxicity' arising from simultaneous inhibition of FLT3 and KIT. We report a novel chemical strategy for selective FLT3 inhibition while avoiding KIT inhibition with the staurosporine analog, Star 27. Star 27 maintains potency against FLT3 in proliferation assays of FLT3-transformed cells compared with KIT-transformed cells, shows no toxicity towards normal human hematopoiesis at concentrations that inhibit primary FLT3-mutant AML blast growth, and is active against mutations that confer resistance to clinical inhibitors. As a more complete understanding of kinase networks emerges, it may be possible to define anti-targets such as KIT in the case of AML to allow improved kinase inhibitor design of clinical agents with enhanced efficacy and reduced toxicity.
Persistent Identifierhttp://hdl.handle.net/10722/245104
ISSN
2019 Impact Factor: 7.08
2015 SCImago Journal Rankings: 6.356
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWarkentin, AA-
dc.contributor.authorLopez, MS-
dc.contributor.authorLasater, EA-
dc.contributor.authorLin, K-
dc.contributor.authorHe, BA-
dc.contributor.authorLeung, AYH-
dc.contributor.authorSmith, CC-
dc.contributor.authorShah, NP-
dc.contributor.authorShokat, KM-
dc.date.accessioned2017-09-18T02:04:41Z-
dc.date.available2017-09-18T02:04:41Z-
dc.date.issued2014-
dc.identifier.citationeLife, 2014, v. 3, p. e03445:1-17-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/10722/245104-
dc.description.abstractActivating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and myelosuppression attributed to a 'synthetic lethal toxicity' arising from simultaneous inhibition of FLT3 and KIT. We report a novel chemical strategy for selective FLT3 inhibition while avoiding KIT inhibition with the staurosporine analog, Star 27. Star 27 maintains potency against FLT3 in proliferation assays of FLT3-transformed cells compared with KIT-transformed cells, shows no toxicity towards normal human hematopoiesis at concentrations that inhibit primary FLT3-mutant AML blast growth, and is active against mutations that confer resistance to clinical inhibitors. As a more complete understanding of kinase networks emerges, it may be possible to define anti-targets such as KIT in the case of AML to allow improved kinase inhibitor design of clinical agents with enhanced efficacy and reduced toxicity.-
dc.languageeng-
dc.publishereLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/-
dc.relation.ispartofeLife-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleOvercoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy-
dc.typeArticle-
dc.identifier.emailHe, BA: alexhe@hku.hk-
dc.identifier.emailLeung, AYH: ayhleung@hku.hk-
dc.identifier.authorityLeung, AYH=rp00265-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7554/eLife.03445-
dc.identifier.pmcidPMC4307180-
dc.identifier.scopuseid_2-s2.0-84953256040-
dc.identifier.hkuros275920-
dc.identifier.volume3-
dc.identifier.spagee03445:1-
dc.identifier.epage17-
dc.publisher.placeCambridge, UK-

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