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Article: Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells

TitleDirected differentiation of human bone marrow stromal cells to fate-committed Schwann cells
Authors
Keywordsbone marrow stromal cell
differentiation
fate commitment
myelination
Schwann cell
Issue Date2017
PublisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com
Citation
Stem Cell Reports, 2017, v. 9 n. 4, p. 1097–1108 How to Cite?
AbstractTransplantation of oligodendrocyte precursors represents a potential therapy for myelin disorders but requires a safe and accessible cell source. Here we report the directed differentiation of neural progenitors derived from adult bone marrow stromal cells (BMSCs) into oligodendrocyte precursors for cell therapy purpose. Neural progenitors among BMSCs could be culture expanded in non-adherent sphere-forming conditions and directed to differentiate along the oligodendrocyte lineage. BMSC-derived oligodendrocyte precursors (BM-OPs) differentiated into myelin basic protein (MBP)-positive oligodendrocyte when co-cultured with purified dorsal root ganglion (DRG) neurons. Injection of BM-OPs into the brain of myelin deficient Shiverer mice resulted in the generation of MBP-positive oligodendrocyte and compact myelin. Our results provided pointers to adult BMSCs as a readily accessible source of OPs towards cell therapy for myelin disorders.
Persistent Identifierhttp://hdl.handle.net/10722/244660
ISSN
2019 Impact Factor: 6.032
2015 SCImago Journal Rankings: 5.523
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCai, S-
dc.contributor.authorTsui, YP-
dc.contributor.authorTam, KW-
dc.contributor.authorShea, GKH-
dc.contributor.authorChang, RSK-
dc.contributor.authorAo, Q-
dc.contributor.authorShum, DKY-
dc.contributor.authorChan, YS-
dc.date.accessioned2017-09-18T01:56:42Z-
dc.date.available2017-09-18T01:56:42Z-
dc.date.issued2017-
dc.identifier.citationStem Cell Reports, 2017, v. 9 n. 4, p. 1097–1108-
dc.identifier.issn2213-6711-
dc.identifier.urihttp://hdl.handle.net/10722/244660-
dc.description.abstractTransplantation of oligodendrocyte precursors represents a potential therapy for myelin disorders but requires a safe and accessible cell source. Here we report the directed differentiation of neural progenitors derived from adult bone marrow stromal cells (BMSCs) into oligodendrocyte precursors for cell therapy purpose. Neural progenitors among BMSCs could be culture expanded in non-adherent sphere-forming conditions and directed to differentiate along the oligodendrocyte lineage. BMSC-derived oligodendrocyte precursors (BM-OPs) differentiated into myelin basic protein (MBP)-positive oligodendrocyte when co-cultured with purified dorsal root ganglion (DRG) neurons. Injection of BM-OPs into the brain of myelin deficient Shiverer mice resulted in the generation of MBP-positive oligodendrocyte and compact myelin. Our results provided pointers to adult BMSCs as a readily accessible source of OPs towards cell therapy for myelin disorders.-
dc.languageeng-
dc.publisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com-
dc.relation.ispartofStem Cell Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbone marrow stromal cell-
dc.subjectdifferentiation-
dc.subjectfate commitment-
dc.subjectmyelination-
dc.subjectSchwann cell-
dc.titleDirected differentiation of human bone marrow stromal cells to fate-committed Schwann cells-
dc.typeArticle-
dc.identifier.emailCai, S: caisa@hku.hk-
dc.identifier.emailTsui, YP: alex2013@hku.hk-
dc.identifier.emailTam, KW: tamkw@hku.hk-
dc.identifier.emailShea, GKH: gkshea@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityShea, GKH=rp01781-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.authorityChan, YS=rp00318-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.stemcr.2017.08.004-
dc.identifier.pmcidPMC5639182-
dc.identifier.scopuseid_2-s2.0-85030867782-
dc.identifier.hkuros276579-
dc.identifier.volume9-
dc.identifier.issue4-
dc.identifier.spage1097–1108-
dc.identifier.epage1097–1108-
dc.identifier.isiWOS:000412660000009-
dc.publisher.placeUnited States-
dc.identifier.issnl2213-6711-

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