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Article: Reprogramming of Central Carbon Metabolism in Cancer Stem Cells

TitleReprogramming of Central Carbon Metabolism in Cancer Stem Cells
Authors
Issue Date2017
Citation
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, v. 1863, p. 1728-1738 How to Cite?
AbstractCancer metabolism has been studied for years and adopted in the clinic for monitoring disease progression and therapy response. Despite our growing knowledge of a distinctly altered metabolic behavior in cancer, drugs targeting cancer metabolism have remained less than promising. Recent efforts in cancer stem cell (CSC) biology suggest that a subpopulation of tumor-initiating cells within the tumor bulk represents the root of tumor recurrence and therapy resistance. In recent years, metabolic phenotype of CSCs of various tumor types has been identified. This breakthrough has shed light on the underlying mechanism by which CSCs maintain stemness, confer resistance to therapies and initiate tumor relapse. The distinct metabolic characteristics of CSCs compared to non-CSCs provide an opportunity to target CSCs more specifically and have become a major focus in cancer research in recent years with substantial efforts conducted towards discovering clinical targets. This perspective article summarizes the current knowledge of CSC metabolism in carcinogenesis and highlights the potential of targeting CSC metabolism for therapy.
Persistent Identifierhttp://hdl.handle.net/10722/244652
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, TL-
dc.contributor.authorCHE, N-
dc.contributor.authorMa, SKY-
dc.date.accessioned2017-09-18T01:56:32Z-
dc.date.available2017-09-18T01:56:32Z-
dc.date.issued2017-
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, v. 1863, p. 1728-1738-
dc.identifier.urihttp://hdl.handle.net/10722/244652-
dc.description.abstractCancer metabolism has been studied for years and adopted in the clinic for monitoring disease progression and therapy response. Despite our growing knowledge of a distinctly altered metabolic behavior in cancer, drugs targeting cancer metabolism have remained less than promising. Recent efforts in cancer stem cell (CSC) biology suggest that a subpopulation of tumor-initiating cells within the tumor bulk represents the root of tumor recurrence and therapy resistance. In recent years, metabolic phenotype of CSCs of various tumor types has been identified. This breakthrough has shed light on the underlying mechanism by which CSCs maintain stemness, confer resistance to therapies and initiate tumor relapse. The distinct metabolic characteristics of CSCs compared to non-CSCs provide an opportunity to target CSCs more specifically and have become a major focus in cancer research in recent years with substantial efforts conducted towards discovering clinical targets. This perspective article summarizes the current knowledge of CSC metabolism in carcinogenesis and highlights the potential of targeting CSC metabolism for therapy.-
dc.languageeng-
dc.relation.ispartofBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease-
dc.titleReprogramming of Central Carbon Metabolism in Cancer Stem Cells-
dc.typeArticle-
dc.identifier.emailWong, TL: tinlwong@hku.hk-
dc.identifier.emailMa, SKY: stefma@hku.hk-
dc.identifier.authorityMa, SKY=rp00506-
dc.identifier.doi10.1016/j.bbadis.2017.05.012-
dc.identifier.hkuros276056-
dc.identifier.volume1863-
dc.identifier.spage1728-
dc.identifier.epage1738-
dc.identifier.isiWOS:000403732800004-

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