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Article: Delivery of poorly soluble compounds by amorphous solid dispersions

TitleDelivery of poorly soluble compounds by amorphous solid dispersions
Authors
Lee, Thomas W.Y.Boersen, Nathan A.Hui, H. W.Chow, S. F.Wan, K. Y.Chow, Albert H.L.
KeywordsPolymer carrier
Amorphization technologies
Amorphous solid dispersion
Glass transition
Molecular mobility
Physical stability
Issue Date2014
Citation
Current Pharmaceutical Design, 2014, v. 20, n. 3, p. 303-324 How to Cite?
DOI: http://dx.doi.org/10.2174/13816128113199990396
AbstractSolid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area. © 2014 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/244162
ISSN
1381-6128
2021 Impact Factor: 3.310
2020 SCImago Journal Rankings: 0.690
ISI Accession Number ID
WOS:000334303800002

 

DC FieldValueLanguage
dc.contributor.authorLee, Thomas W.Y.-
dc.contributor.authorBoersen, Nathan A.-
dc.contributor.authorHui, H. W.-
dc.contributor.authorChow, S. F.-
dc.contributor.authorWan, K. Y.-
dc.contributor.authorChow, Albert H.L.-
dc.date.accessioned2017-08-31T08:56:13Z-
dc.date.available2017-08-31T08:56:13Z-
dc.date.issued2014-
dc.identifier.citationCurrent Pharmaceutical Design, 2014, v. 20, n. 3, p. 303-324-
dc.identifier.issn1381-6128-
dc.identifier.urihttp://hdl.handle.net/10722/244162-
dc.description.abstractSolid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area. © 2014 Bentham Science Publishers.-
dc.languageeng-
dc.relation.ispartofCurrent Pharmaceutical Design-
dc.subjectPolymer carrier-
dc.subjectAmorphization technologies-
dc.subjectAmorphous solid dispersion-
dc.subjectGlass transition-
dc.subjectMolecular mobility-
dc.subjectPhysical stability-
dc.titleDelivery of poorly soluble compounds by amorphous solid dispersions-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/13816128113199990396-
dc.identifier.pmid23651395-
dc.identifier.scopuseid_2-s2.0-84894101139-
dc.identifier.volume20-
dc.identifier.issue3-
dc.identifier.spage303-
dc.identifier.epage324-
dc.identifier.eissn1873-4286-
dc.identifier.isiWOS:000334303800002-
dc.identifier.issnl1381-6128-

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