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Article: Response and adaptation of skeletal muscle to denervation stress: The role of apoptosis in muscle loss

TitleResponse and adaptation of skeletal muscle to denervation stress: The role of apoptosis in muscle loss
Authors
KeywordsReview
Nerve innervation
Denervation
Apoptosis
Skeletal myofiber
Satellite cell
Issue Date2009
Citation
Frontiers in Bioscience, 2009, v. 14, n. 2, p. 432-452 How to Cite?
AbstractApoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. The comprehensive investigation of apoptosis has been emerged in the field of skeletal muscle biology. Results have been consistent in demonstrating the activation of apoptotic machinery in different pathologic and physiologic muscle atrophic conditions including muscle disuse, hindlimb unloading, muscle dystrophy, sarcopenia, and neuromuscular diseases. Together with the other identified muscle atrophyrelated signaling mechanisms such as NFκB, FOXOs/MuRF1/MAFbx and ubiquitin-proteasome, apoptosis has been advocated as an important candidate in regulating denervation-induced muscle loss. The purpose of this article is to review the role and signaling mechanisms of apoptosis during denervation in skeletal muscle including myofibers and satellite cells.
Persistent Identifierhttp://hdl.handle.net/10722/244096
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583

 

DC FieldValueLanguage
dc.contributor.authorSiu, Parco M.-
dc.contributor.authorAlway, Stephen E.-
dc.date.accessioned2017-08-31T08:56:02Z-
dc.date.available2017-08-31T08:56:02Z-
dc.date.issued2009-
dc.identifier.citationFrontiers in Bioscience, 2009, v. 14, n. 2, p. 432-452-
dc.identifier.issn1093-9946-
dc.identifier.urihttp://hdl.handle.net/10722/244096-
dc.description.abstractApoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. The comprehensive investigation of apoptosis has been emerged in the field of skeletal muscle biology. Results have been consistent in demonstrating the activation of apoptotic machinery in different pathologic and physiologic muscle atrophic conditions including muscle disuse, hindlimb unloading, muscle dystrophy, sarcopenia, and neuromuscular diseases. Together with the other identified muscle atrophyrelated signaling mechanisms such as NFκB, FOXOs/MuRF1/MAFbx and ubiquitin-proteasome, apoptosis has been advocated as an important candidate in regulating denervation-induced muscle loss. The purpose of this article is to review the role and signaling mechanisms of apoptosis during denervation in skeletal muscle including myofibers and satellite cells.-
dc.languageeng-
dc.relation.ispartofFrontiers in Bioscience-
dc.subjectReview-
dc.subjectNerve innervation-
dc.subjectDenervation-
dc.subjectApoptosis-
dc.subjectSkeletal myofiber-
dc.subjectSatellite cell-
dc.titleResponse and adaptation of skeletal muscle to denervation stress: The role of apoptosis in muscle loss-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.2741/3253-
dc.identifier.pmid19273076-
dc.identifier.scopuseid_2-s2.0-63849145831-
dc.identifier.volume14-
dc.identifier.issue2-
dc.identifier.spage432-
dc.identifier.epage452-

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