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Article: Parental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong

TitleParental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong
Authors
Keywordsparental decisions
pregnancy termination
prenatal diagnosis
sex chromosome aneuploidy
Issue Date2017
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JOG.html
Citation
Journal of Obstetrics and Gynaecology Research, 2017, v. 43 n. 12, p. 1821-1829 How to Cite?
AbstractAim: According to the published work, pregnancy termination rates due to prenatal diagnosis of fetal sex chromosome aneuploidies (SCA) vary widely. Some potentially modifiable and non-modifiable factors have been reported to be associated with parental decision. This study aimed to evaluate the rate of pregnancy termination for fetal SCA and the factors influencing parents' decisions in Hong Kong. Methods: This was a 21-year retrospective cohort study of parents' decisions following prenatal diagnosis of SCA. Univariate and multivariate analyses for the association between demographic factors, prenatal factors, or counseling provided and decision-making were conducted. Results: The study included 399 pregnancies with prenatal diagnosis of SCA and the overall termination rate was 55.6% (91.7%, 48.0%, 23.4%, 4.8%, and 22.7% for 45,X, 47,XXY, 47,XXX, 47,XYY, and mosaicism, respectively). Pregnancies with ultrasound abnormalities were associated with higher termination rates than pregnancies with normal ultrasound findings (91.3% vs 28.3%, P < 0.0001). From multivariate regression analysis on 226 pregnancies with normal ultrasound examination, a higher likelihood to terminate was found in pregnancies affected by 45,X and 47,XXY (adjusted odds ratio, 4.72, P < 0.0001). Increased maternal age and history of infertility were associated with lower likelihood to terminate (adjusted odds ratio, 0.9, P = 0.012; and 5.12, P = 0.038, respectively). The pregnancy termination rate declined over time. Conclusion: A significant correlation was found between the termination of SCA-affected pregnancy and the presence of fetal sonographic abnormalities, type of SCA, maternal age, and presence of infertility. © 2017 Japan Society of Obstetrics and Gynecology
Persistent Identifierhttp://hdl.handle.net/10722/243782
ISSN
2017 Impact Factor: 1.091
2015 SCImago Journal Rankings: 0.521
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, PL-
dc.contributor.authorCheng, YKY-
dc.contributor.authorCheuk, KY-
dc.contributor.authorChiu, WK-
dc.contributor.authorMak, SL-
dc.contributor.authorMok, SL-
dc.contributor.authorLo, TK-
dc.contributor.authorYung, WK-
dc.contributor.authorLo, FM-
dc.contributor.authorChung, BHY-
dc.contributor.authorKan, SYA-
dc.contributor.authorLee, CP-
dc.contributor.authorTang, MHY-
dc.date.accessioned2017-08-25T02:59:27Z-
dc.date.available2017-08-25T02:59:27Z-
dc.date.issued2017-
dc.identifier.citationJournal of Obstetrics and Gynaecology Research, 2017, v. 43 n. 12, p. 1821-1829-
dc.identifier.issn1341-8076-
dc.identifier.urihttp://hdl.handle.net/10722/243782-
dc.description.abstractAim: According to the published work, pregnancy termination rates due to prenatal diagnosis of fetal sex chromosome aneuploidies (SCA) vary widely. Some potentially modifiable and non-modifiable factors have been reported to be associated with parental decision. This study aimed to evaluate the rate of pregnancy termination for fetal SCA and the factors influencing parents' decisions in Hong Kong. Methods: This was a 21-year retrospective cohort study of parents' decisions following prenatal diagnosis of SCA. Univariate and multivariate analyses for the association between demographic factors, prenatal factors, or counseling provided and decision-making were conducted. Results: The study included 399 pregnancies with prenatal diagnosis of SCA and the overall termination rate was 55.6% (91.7%, 48.0%, 23.4%, 4.8%, and 22.7% for 45,X, 47,XXY, 47,XXX, 47,XYY, and mosaicism, respectively). Pregnancies with ultrasound abnormalities were associated with higher termination rates than pregnancies with normal ultrasound findings (91.3% vs 28.3%, P < 0.0001). From multivariate regression analysis on 226 pregnancies with normal ultrasound examination, a higher likelihood to terminate was found in pregnancies affected by 45,X and 47,XXY (adjusted odds ratio, 4.72, P < 0.0001). Increased maternal age and history of infertility were associated with lower likelihood to terminate (adjusted odds ratio, 0.9, P = 0.012; and 5.12, P = 0.038, respectively). The pregnancy termination rate declined over time. Conclusion: A significant correlation was found between the termination of SCA-affected pregnancy and the presence of fetal sonographic abnormalities, type of SCA, maternal age, and presence of infertility. © 2017 Japan Society of Obstetrics and Gynecology-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JOG.html-
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article].-
dc.subjectparental decisions-
dc.subjectpregnancy termination-
dc.subjectprenatal diagnosis-
dc.subjectsex chromosome aneuploidy-
dc.titleParental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong-
dc.typeArticle-
dc.identifier.emailLo, TK: a915185@hkucc.hku.hk-
dc.identifier.emailChung, BHY: bhychung@hku.hk-
dc.identifier.emailKan, SYA: kansya@hkucc.hku.hk-
dc.identifier.emailLee, CP: chinpeng@hkucc.hku.hk-
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hk-
dc.identifier.authorityChung, BHY=rp00473-
dc.identifier.authorityLee, CP=rp01862-
dc.identifier.authorityTang, MHY=rp01701-
dc.identifier.doi10.1111/jog.13451-
dc.identifier.scopuseid_2-s2.0-85029295477-
dc.identifier.hkuros274580-
dc.identifier.volume43-
dc.identifier.issue12-
dc.identifier.spage1821-
dc.identifier.epage1829-
dc.identifier.isiWOS:000418412200004-
dc.publisher.placeAustralia-

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