File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cyclometalated Palladium(II) N-Heterocyclic Carbene Complexes: Anticancer Agents for Potent In Vitro Cytotoxicity and In Vivo Tumor Growth Suppression

TitleCyclometalated Palladium(II) N-Heterocyclic Carbene Complexes: Anticancer Agents for Potent In Vitro Cytotoxicity and In Vivo Tumor Growth Suppression
Authors
KeywordsAnticancer agents
N-heterocyclic carbenes
Palladium
Proteomics
Thiol reactivity
Issue Date2016
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie (International Edition), 2016, v. 55 n. 39, p. 11935-11939 How to Cite?
AbstractPalladium(II) complexes are generally reactive toward substitution/reduction, and their biological applications are seldom explored. A new series of palladium(II) N‐heterocyclic carbene (NHC) complexes that are stable in the presence of biological thiols are reported. A representative complex, [Pd(C^N^N)(N,N′‐nBu2NHC)](CF3SO3) (Pd1 d, HC^N^N=6‐phenyl‐2,2′‐bipyridine, N,N′‐nBu2NHC=N,N′‐di‐n‐butylimidazolylidene), displays potent killing activity toward cancer cell lines (IC50=0.09–0.5 μm) but is less cytotoxic toward a normal human fibroblast cell line (CCD‐19Lu, IC50=11.8 μm). In vivo anticancer studies revealed that Pd1 d significantly inhibited tumor growth in a nude mice model. Proteomics data and in vitro biochemical assays reveal that Pd1 d exerts anticancer effects, including inhibition of an epidermal growth factor receptor pathway, induction of mitochondrial dysfunction, and antiangiogenic activity to endothelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/242986
ISSN
2019 Impact Factor: 12.959
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFong, TTH-
dc.contributor.authorLok, CN-
dc.contributor.authorChung, CYS-
dc.contributor.authorFung, YME-
dc.contributor.authorChow, PK-
dc.contributor.authorWan, PK-
dc.contributor.authorChe, CM-
dc.date.accessioned2017-08-25T02:48:19Z-
dc.date.available2017-08-25T02:48:19Z-
dc.date.issued2016-
dc.identifier.citationAngewandte Chemie (International Edition), 2016, v. 55 n. 39, p. 11935-11939-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/242986-
dc.description.abstractPalladium(II) complexes are generally reactive toward substitution/reduction, and their biological applications are seldom explored. A new series of palladium(II) N‐heterocyclic carbene (NHC) complexes that are stable in the presence of biological thiols are reported. A representative complex, [Pd(C^N^N)(N,N′‐nBu2NHC)](CF3SO3) (Pd1 d, HC^N^N=6‐phenyl‐2,2′‐bipyridine, N,N′‐nBu2NHC=N,N′‐di‐n‐butylimidazolylidene), displays potent killing activity toward cancer cell lines (IC50=0.09–0.5 μm) but is less cytotoxic toward a normal human fibroblast cell line (CCD‐19Lu, IC50=11.8 μm). In vivo anticancer studies revealed that Pd1 d significantly inhibited tumor growth in a nude mice model. Proteomics data and in vitro biochemical assays reveal that Pd1 d exerts anticancer effects, including inhibition of an epidermal growth factor receptor pathway, induction of mitochondrial dysfunction, and antiangiogenic activity to endothelial cells.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.subjectAnticancer agents-
dc.subjectN-heterocyclic carbenes-
dc.subjectPalladium-
dc.subjectProteomics-
dc.subjectThiol reactivity-
dc.titleCyclometalated Palladium(II) N-Heterocyclic Carbene Complexes: Anticancer Agents for Potent In Vitro Cytotoxicity and In Vivo Tumor Growth Suppression-
dc.typeArticle-
dc.identifier.emailLok, CN: cnlok@hku.hk-
dc.identifier.emailChung, CYS: cyschung@hku.hk-
dc.identifier.emailFung, YME: eva.fungym@hku.hk-
dc.identifier.emailChow, PK: h0560334@hku.hk-
dc.identifier.emailChe, CM: chemhead@hku.hk-
dc.identifier.authorityLok, CN=rp00752-
dc.identifier.authorityChung, CYS=rp02672-
dc.identifier.authorityFung, YME=rp01986-
dc.identifier.authorityChe, CM=rp00670-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201602814-
dc.identifier.pmid27571430-
dc.identifier.scopuseid_2-s2.0-84992063474-
dc.identifier.hkuros273636-
dc.identifier.volume55-
dc.identifier.issue39-
dc.identifier.spage11935-
dc.identifier.epage11939-
dc.identifier.isiWOS:000384713100041-
dc.publisher.placeGermany-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats