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Article: Serum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease

TitleSerum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease
Authors
Issue Date2017
PublisherE-Century Publishing Corporation. The Journal's web site is located at http://www.ajtr.org
Citation
American Journal of Translational Research, 2017, v. 9 n. 6, p. 2920-2932 How to Cite?
AbstractWNT1-inducible signaling pathway protein-1 (WISP-1) is an extracellular matrix-related protein that plays multiple roles in cellular physiology and pathology. Accumulating evidence shows that WISP-1 is involved in the process underlying fibrotic diseases. However, the correlation between WISP-1 and renal fibrosis is unknown. In this study, we hypothesized that WISP-1 levels might be correlated with renal fibrosis and could be used as a noninvasive biomarker to screen for renal fibrosis in patients with chronic kidney disease (CKD). We first measured the WISP-1 expression levels using a transforming growth factor-β (TGF-β)-induced renal fibrosis tubular epithelial cell (TEC) model and a mouse model of obstructive nephropathy. We then evaluated the correlation between serum WISP-1 levels and fibrosis scores in biopsy-proven renal fibrosis of patients with CKD. Based on the findings from both in vivo and in vitro studies, the levels of WISP-1 and fibrotic parameters (collagen I, fibronectin and α-smooth muscle actin) were significantly increased in the fibrotic models. Consistently, patients with focal proliferative IgA nephropathy, focal segmental glomerular sclerosis and diabetic nephropathy displayed markedly elevated serum WISP-1 levels and fibrosis scores of renal biopsies compared with normal subjects and patients with minimal change disease (P<0.05). Importantly, the serum WISP-1 levels were positively correlated with fibrosis scores in the renal biopsies of these patients (r=0.475, P=0.0001). Thus, serum WISP-1 levels may be used as a potential noninvasive biomarker of renal fibrosis in patients with CKD.
Persistent Identifierhttp://hdl.handle.net/10722/242438
ISSN
2017 Impact Factor: 3.061
2015 SCImago Journal Rankings: 1.442
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorZhong, X-
dc.contributor.authorTu, YJ-
dc.contributor.authorLi, Y-
dc.contributor.authorZhang, P-
dc.contributor.authorWang, W-
dc.contributor.authorChen, SS-
dc.contributor.authorLi, L-
dc.contributor.authorChung, ACK-
dc.contributor.authorLan, HY-
dc.contributor.authorChen, H-
dc.contributor.authorLi, GS-
dc.contributor.authorWang, L-
dc.date.accessioned2017-07-24T01:39:47Z-
dc.date.available2017-07-24T01:39:47Z-
dc.date.issued2017-
dc.identifier.citationAmerican Journal of Translational Research, 2017, v. 9 n. 6, p. 2920-2932-
dc.identifier.issn1943-8141-
dc.identifier.urihttp://hdl.handle.net/10722/242438-
dc.description.abstractWNT1-inducible signaling pathway protein-1 (WISP-1) is an extracellular matrix-related protein that plays multiple roles in cellular physiology and pathology. Accumulating evidence shows that WISP-1 is involved in the process underlying fibrotic diseases. However, the correlation between WISP-1 and renal fibrosis is unknown. In this study, we hypothesized that WISP-1 levels might be correlated with renal fibrosis and could be used as a noninvasive biomarker to screen for renal fibrosis in patients with chronic kidney disease (CKD). We first measured the WISP-1 expression levels using a transforming growth factor-β (TGF-β)-induced renal fibrosis tubular epithelial cell (TEC) model and a mouse model of obstructive nephropathy. We then evaluated the correlation between serum WISP-1 levels and fibrosis scores in biopsy-proven renal fibrosis of patients with CKD. Based on the findings from both in vivo and in vitro studies, the levels of WISP-1 and fibrotic parameters (collagen I, fibronectin and α-smooth muscle actin) were significantly increased in the fibrotic models. Consistently, patients with focal proliferative IgA nephropathy, focal segmental glomerular sclerosis and diabetic nephropathy displayed markedly elevated serum WISP-1 levels and fibrosis scores of renal biopsies compared with normal subjects and patients with minimal change disease (P<0.05). Importantly, the serum WISP-1 levels were positively correlated with fibrosis scores in the renal biopsies of these patients (r=0.475, P=0.0001). Thus, serum WISP-1 levels may be used as a potential noninvasive biomarker of renal fibrosis in patients with CKD.-
dc.languageeng-
dc.publisherE-Century Publishing Corporation. The Journal's web site is located at http://www.ajtr.org-
dc.relation.ispartofAmerican Journal of Translational Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSerum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease-
dc.typeArticle-
dc.identifier.emailChen, H: haiyong@hku.hk-
dc.identifier.authorityChen, H=rp01923-
dc.description.naturepublished_or_final_version-
dc.identifier.pmcidPMC5489892-
dc.identifier.hkuros273594-
dc.identifier.volume9-
dc.identifier.issue6-
dc.identifier.spage2920-
dc.identifier.epage2932-
dc.publisher.placeUnited States-

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