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Article: Age at menarche and cardiovascular risk factors using Mendelian randomization in the Guangzhou Biobank Cohort Study

TitleAge at menarche and cardiovascular risk factors using Mendelian randomization in the Guangzhou Biobank Cohort Study
Authors
Issue Date2017
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ypmed
Citation
Preventive Medicine, 2017, v. 101, p. 142-148 How to Cite?
AbstractObservational studies show earlier age at menarche associated with higher risk of cardiovascular disease although these studies could be confounded by childhood obesity or childhood socioeconomic position. We tested the hypothesis that earlier age at menarche is associated with poorer cardiovascular risk factors using a Mendelian randomization design. We conducted a Mendelian randomization study in a large Southern Chinese cohort, the Guangzhou Biobank Cohort Study (n = 12,279), to clarify the causal role of menarche in cardiovascular disease risk factors including blood pressure, lipids, fasting glucose, adiposity and type 2 diabetes. A genetic allele score was obtained from single nucleotide polymorphisms associated with age at menarche using stepwise regression and with cross validation. Estimates of the association of age at menarche with cardiovascular disease risk factors were obtained using two stage least squares regression. Height was included as a positive control outcome. The F-statistic for the allele score (rs17268785, rs1859345, rs2090409, rs4452860 and rs4946651) was 19.9. Older age at menarche was associated with lower glucose (− 0.39 mmol/L per year older menarche, 95% confidence interval (CI) − 0.78 to − 0.001) but not clearly with any other cardiovascular risk factors. Older age at menarche was also associated with taller height. Age at menarche did not appear to affect cardiovascular disease risk factors except for glucose in an inverse manner. However, these results need to be confirmed in larger Mendelian randomization studies.
Persistent Identifierhttp://hdl.handle.net/10722/242097
ISSN
2017 Impact Factor: 3.483
2015 SCImago Journal Rankings: 1.621

 

DC FieldValueLanguage
dc.contributor.authorAu Yeung, SLR-
dc.contributor.authorJiang, C-
dc.contributor.authorCheng, KK-
dc.contributor.authorXu, L-
dc.contributor.authorZhang, W-
dc.contributor.authorLam, TH-
dc.contributor.authorLeung, GM-
dc.contributor.authorSchooling, CM-
dc.date.accessioned2017-07-24T01:35:12Z-
dc.date.available2017-07-24T01:35:12Z-
dc.date.issued2017-
dc.identifier.citationPreventive Medicine, 2017, v. 101, p. 142-148-
dc.identifier.issn0091-7435-
dc.identifier.urihttp://hdl.handle.net/10722/242097-
dc.description.abstractObservational studies show earlier age at menarche associated with higher risk of cardiovascular disease although these studies could be confounded by childhood obesity or childhood socioeconomic position. We tested the hypothesis that earlier age at menarche is associated with poorer cardiovascular risk factors using a Mendelian randomization design. We conducted a Mendelian randomization study in a large Southern Chinese cohort, the Guangzhou Biobank Cohort Study (n = 12,279), to clarify the causal role of menarche in cardiovascular disease risk factors including blood pressure, lipids, fasting glucose, adiposity and type 2 diabetes. A genetic allele score was obtained from single nucleotide polymorphisms associated with age at menarche using stepwise regression and with cross validation. Estimates of the association of age at menarche with cardiovascular disease risk factors were obtained using two stage least squares regression. Height was included as a positive control outcome. The F-statistic for the allele score (rs17268785, rs1859345, rs2090409, rs4452860 and rs4946651) was 19.9. Older age at menarche was associated with lower glucose (− 0.39 mmol/L per year older menarche, 95% confidence interval (CI) − 0.78 to − 0.001) but not clearly with any other cardiovascular risk factors. Older age at menarche was also associated with taller height. Age at menarche did not appear to affect cardiovascular disease risk factors except for glucose in an inverse manner. However, these results need to be confirmed in larger Mendelian randomization studies.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ypmed-
dc.relation.ispartofPreventive Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAge at menarche and cardiovascular risk factors using Mendelian randomization in the Guangzhou Biobank Cohort Study-
dc.typeArticle-
dc.identifier.emailAu Yeung, SLR: ayslryan@hku.hk-
dc.identifier.emailJiang, C: cqjiang@hkucc.hku.hk-
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hk-
dc.identifier.emailXu, L: linxu@hku.hk-
dc.identifier.emailZhang, W: zhangws9@hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.authorityAu Yeung, SLR=rp02224-
dc.identifier.authorityXu, L=rp02030-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authoritySchooling, CM=rp00504-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.ypmed.2017.06.006-
dc.identifier.hkuros273265-
dc.identifier.volume101-
dc.identifier.spage142-
dc.identifier.epage148-
dc.publisher.placeUnited States-

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