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Conference Paper: Differential age-related change in bone mineral density and total body lean mass between adults with and without down syndrome

TitleDifferential age-related change in bone mineral density and total body lean mass between adults with and without down syndrome
Authors
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://gerontologist.gerontologyjournals.org
Citation
The 68th Annual Scientific Meeting of the Gerontological Society of America (GSA 2015), Orlando, FL., 18-22 November 2015. In The Gerontologist, 2015, v. 55 n. suppl. 2, p. 850 How to Cite?
AbstractDown syndrome (DS) is a condition associated with accelerated ageing but data on the pattern of age-related change in bone and lean mass are scarce. Method: We performed quadratic regression analysis to compare the change in whole body bone mineral density (BMD) and total body lean mass (TBLM) with age between adults with and without DS. Results: Whole body BMD (g/cm2) increased 0.008 in healthy adults aged 20-29 years but the amount decreased by 0.004 between 30-39 years and 0.026 between 40-50 years. Whole body BMD of DS adults showed more increase at younger age (20-29 y, 0.018) and sharper decline at older age (30-39 y, -0.028; 40-50 y, -0.085). TBLM was not associated with age among healthy adults but inversely related to age among DS adults. Implications: The observed early loss of BMD and TLBM delineated the extent of premature ageing in DS.
Persistent Identifierhttp://hdl.handle.net/10722/242033
ISSN
2017 Impact Factor: 4.078
2015 SCImago Journal Rankings: 1.584

 

DC FieldValueLanguage
dc.contributor.authorTse, M-
dc.contributor.authorTang, JY-
dc.contributor.authorLuo, H-
dc.contributor.authorWong, G-
dc.contributor.authorJoe, GM-
dc.contributor.authorLum, TYS-
dc.date.accessioned2017-07-14T09:39:29Z-
dc.date.available2017-07-14T09:39:29Z-
dc.date.issued2015-
dc.identifier.citationThe 68th Annual Scientific Meeting of the Gerontological Society of America (GSA 2015), Orlando, FL., 18-22 November 2015. In The Gerontologist, 2015, v. 55 n. suppl. 2, p. 850-
dc.identifier.issn0016-9013-
dc.identifier.urihttp://hdl.handle.net/10722/242033-
dc.description.abstractDown syndrome (DS) is a condition associated with accelerated ageing but data on the pattern of age-related change in bone and lean mass are scarce. Method: We performed quadratic regression analysis to compare the change in whole body bone mineral density (BMD) and total body lean mass (TBLM) with age between adults with and without DS. Results: Whole body BMD (g/cm2) increased 0.008 in healthy adults aged 20-29 years but the amount decreased by 0.004 between 30-39 years and 0.026 between 40-50 years. Whole body BMD of DS adults showed more increase at younger age (20-29 y, 0.018) and sharper decline at older age (30-39 y, -0.028; 40-50 y, -0.085). TBLM was not associated with age among healthy adults but inversely related to age among DS adults. Implications: The observed early loss of BMD and TLBM delineated the extent of premature ageing in DS.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://gerontologist.gerontologyjournals.org-
dc.relation.ispartofThe Gerontologist-
dc.titleDifferential age-related change in bone mineral density and total body lean mass between adults with and without down syndrome-
dc.typeConference_Paper-
dc.identifier.emailJoe, GM: glenj@hkucc.hku.hk-
dc.identifier.emailLum, TYS: tlum@hku.hk-
dc.identifier.authorityLum, TYS=rp01513-
dc.identifier.doi10.1093/geront/gnv480.03-
dc.identifier.volume55-
dc.identifier.issuesuppl. 2-
dc.identifier.spage850-
dc.identifier.epage850-
dc.publisher.placeUnited States-

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